Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DMEN035)
DME Name Protein msp1 (msp1), Schizosaccharomyces pombe
Gene Name msp1
UniProt ID
MSP1_SCHPO
EC Number    EC: 3.1.6.2     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Ester bond hydrolase
Sulfuric ester hydrolase
EC: 3.1.6.2
Lineage    Species: Schizosaccharomyces pombe     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Fungi
Phylum: Ascomycota
Class: Schizosaccharomycetes
Order: Schizosaccharomycetales
Family: Schizosaccharomycetaceae
Genus: Schizosaccharomyces
Species: Schizosaccharomyces pombe
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Sequence
MGISWFLSRFRIRTVAPSSFLKPRGLVYRPSQIRRRVSLLSLSGFHPYRAYSILGPKTPT
AFNSANTVRFFSFSSISRLVFRSLRLPVAGFSLVAGGAAYIGAQVQRASDYTKDIFDKTF
GILDSTWEKTRETVASVTNVQLPEISMPLWLEKILRLDEESAERRRVLQAERAKEHRSNS
NDKQKSSDNDEDPNDTTVGIGAALAASILSVDSVDGEDTLTADEKRKLAQESKEDRMMLF
TKKMIEIRNILQDIQDNNSAVTLPSIVVIGSQSSGKSSVLEAIVGHEFLPKGSNMVTRRP
IELTLVHSADTAIPYGEFSGVQLGKITDFSKIQHILTDLNMAVPSSQGVDDNPIRLTIYA
SHIPNLSLIDLPGYIQIHSEDQPADLDMKISKLCEKYIREPNIILAVCAADVDLANSAAL
RASRRVDPLGLRTIGVVTKMDLVPPSKAISILHNNNYPLHYGYIGVISRIVPTGRFSAGQ
NLTDLVSTQENSYFSTHQQFADARIGNYLGIQSLRKCLINVLEYTMSKNLQHTADSIRTE
LEECNYQYKVQYNDRVLTADSYIAEGLDIFKAAFKEFTQKFGKSEVRDLLKSSLNEKVMD
LLAERYWTDDDISNWSKHTNALDEHWKYKLDSCVSTLTRMGLGRVSTLLVTDSISKCIDE
ITKASPFADHPAAMQYIMNAAQDILRRRFHATSEQVENCVKPYKYDVEVNDDEWKSSRGQ
AEKLLQRELGLCQSALEKIKNAVGSRRMNQVLQYLEEQKTSSEPLPASYSTALLEQGRML
QYLKMREDILKLRISVLKSRACKHKEAKYTCPEIFLNAVSDKLVNTAVLFINIELLSEFY
YQFPRELDQRLIHSLSSEQLNAFVNENPRLKSQLQLQHKRQCLELALQKINSLVILEQQA
DSD
Function Dynamin-related GTPase required for mitochondrial fusion. Coordinates interaction between the inner and outer mitochondrial membrane to promote the formation of the double membrane.
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
A-estradiol
 Drug Info Investigative Discovery agent ICD: N.A. [1]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR000098 A-estradiol Estradiol-2,3-semiquinone Unclear - Unclear A-estradiol [2]
References
1 Cytochrome P450-mediated metabolism of estrogens and its regulation in human Cancer Lett. 2005 Sep 28;227(2):115-24. doi: 10.1016/j.canlet.2004.10.007.
2 Cytochrome P450-mediated metabolism of estrogens and its regulation in human. Cancer Lett. 2005 Sep 28;227(2):115-24.

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