Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DMEN174)
DME Name Mevalonate 3-kinase (Ta1305), Thermoplasma acidophilum
Gene Name Ta1305
UniProt ID
MV3K_THEAC
EC Number    EC: 2.7.1.185     (Click to Show/Hide the Complete EC Tree)
Transferase
Kinase
Phosphotransferase
EC: 2.7.1.185
Lineage    Species: Thermoplasma acidophilum     (Click to Show/Hide the Complete Species Lineage)
Kingdom: .
Phylum: .
Class: .
Order: .
Family: .
Genus: .
Species: Thermoplasma acidophilum
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Sequence
MTYRSIGSTAYPTIGVVLLGGIANPVTRTPLHTSAGIAYSDSCGSIRSETRIYADEATHI
YFNGTESTDDNRSVRRVLDRYSSVFEEAFGTKTVSYSSQNFGILSGSSDAGAASIGAAIL
GLKPDLDPHDVENDLRAVSESAGRSLFGGLTITWSDGFHAYTEKILDPEAFSGYSIVAFA
FDYQRNPSDVIHQNIVRSDLYPARKKHADEHAHMIKEYAKTNDIKGIFDLAQEDTEEYHS
ILRGVGVNVIRENMQKLISYLKLIRKDYWNAYIVTGGSNVYVAVESENADRLFSIENTFG
SKKKMLRIVGGAWHRRPE
Structure
4RKP ; 4RKS ; 4RKZ
Function Catalyzes the phosphorylation of mevalonate (MVA) to yield mevalonate-3-phosphate. Functions in an alternative mevalonate pathway, only present in extreme acidophiles of the Thermoplasmatales order, which passes through mevalonate 3-phosphate rather than mevalonate 5-phosphate.
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
Mevalonate
 Drug Info Investigative Discovery agent ICD: N.A. [1]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR012882 Mevalonate Mevalonate 3-phosphate Unclear - Unclear Mevalonate [1]
References
1 Evidence of a novel mevalonate pathway in archaea

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