Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DMEN240)
DME Name 20-ketosteroid reductase (20-hydroxysteroid dehydrogenase) (kduD), Bacteroides fragilis
Gene Name kduD
Lineage    Species: Bacteroides fragilis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Bacteroidaceae
Genus: Bacteroides
Species: Bacteroides fragilis
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Methylprednisolone
 Drug Info Approved Lymphoblastic Lymphoma ICD11: 2A70 [1], [2]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR004693 Methylprednisolone Methylprednisolone M3 Metabolite Reduction - 20-reduction Methylprednisolone [1], [2]
MR004686 Methylprednisolone M1 Metabolite Methylprednisolone M11 Metabolite Reduction - 20-reduction Methylprednisolone [1], [2]
MR004687 Methylprednisolone M1 Metabolite Methylprednisolone M12 Metabolite Reduction - 20-reduction Methylprednisolone [1], [2]
MR004691 Methylprednisolone M13 Metabolite Methylprednisolone M14 Metabolite Reduction - 20-reduction Methylprednisolone [1], [2]
MR004683 Methylprednisolone M4 Metabolite Methylprednisolone M5 Metabolite Reduction - 20-reduction Methylprednisolone [1], [2]
MR004684 Methylprednisolone M5 Metabolite Methylprednisolone M6 Metabolite Reduction - 20-reduction Methylprednisolone [1], [2]
MR004680 Methylprednisolone M7 Metabolite Methylprednisolone M10 Metabolite Reduction - 20-reduction Methylprednisolone [1], [2]
MR004681 Methylprednisolone M7 Metabolite Methylprednisolone M9 Metabolite Reduction - 20-reduction Methylprednisolone [1], [2]
⏷ Show the Full List of 8 MR(s)
References
1 Urinary profile of methylprednisolone and its metabolites after oral and topical administrations
2 Carbonyl reduction pathways in drug metabolism

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.