Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DMEN258)
DME Name 8-oxo-dGDP phosphatase NUDT18 (NUDT18), Homo sapiens
Gene Name NUDT18
UniProt ID
NUD18_HUMAN
EC Number    EC: 3.6.1.58     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Acid anhydride hydrolase
Acid anhydride hydrolase
EC: 3.6.1.58
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Sequence
MASEGLAGALASVLAGQGSSVHSCDSAPAGEPPAPVRLRKNVCYVVLAVFLSEQDEVLLI
QEAKRECRGSWYLPAGRMEPGETIVEALQREVKEEAGLHCEPETLLSVEERGPSWVRFVF
LARPTGGILKTSKEADAESLQAAWYPRTSLPTPLRAHDILHLVELAAQYRQQARHPLILP
QELPCDLVCQRLVATFTSAQTVWVLVGTVGMPHLPVTACGLDPMEQRGGMKMAVLRLLQE
CLTLHHLVVEIKGLLGLQHLGRDHSDGICLNVLVTVAFRSPGIQDEPPKVRGENFSWWKV
MEEDLQSQLLQRLQGSSVVPVNR
Structure
3GG6 ; 4HVY
Function Mediates the hydrolysis of oxidized nucleoside diphosphate derivatives. Hydrolyzes 8-oxo-7,8-dihydroguanine (8-oxo-Gua)-containing deoxyribo- and ribonucleoside diphosphates to the monophosphates. Hydrolyzes 8-oxo-dGDP and 8-oxo-GDP with the same efficiencies. Hydrolyzes also 8-OH-dADP and 2-OH-dADP. Exhibited no or minimal hydrolysis activity against 8-oxo-dGTP, 8-oxo-GTP, dGTP, GTP, dGDP and GDP. Probably removes oxidized guanine nucleotides from both the DNA and RNA precursor pools.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Remdesivir
 Drug Info Approved Coronavirus Disease 2019 (COVID-19) ICD11: 1D6Y [1]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR013216 Remdesivir Nucleoside Triphosphate Remdesivir-DP Hydrolysis - Hydrolysis Remdesivir [1]
MR013217 Remdesivir Nucleoside Triphosphate Remdesivir-MP Hydrolysis - Hydrolysis Remdesivir [1]
References
1 Nudix hydrolase 18 catalyzes the hydrolysis of active triphosphate metabolites of the antivirals remdesivir, ribavirin, and molnupiravir

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