Details of the Drug Metabolite (DM)

General Information of Drug Metabolite (DM) (ID: DM000916)
DM Name
7-hydroxyethinylestradiol
Structure
3D MOL is unavailable 2D MOL is unavailable
Full List of Drug-Metabolizing Enzyme (DME) Related to This DM
DME(s) Producing This DM through Metabolism
DME Name DME ID Reactant Reaction Related Drug REF
Cytochrome P450 1A2 (CYP1A2) DME0003
Ethinyl estradiol
Oxidation - 7-Hydroxylation Ethinyl estradiol [1]
Cytochrome P450 1A2 (CYP1A2) DME0003
17alpha-Ethinylestradiol
Oxidation - 7-Hydroxylation Mestranol [2] , [3]
Cytochrome P450 2C8 (CYP2C8) DME0018
Ethinyl estradiol
Oxidation - 7-Hydroxylation Ethinyl estradiol [1]
Cytochrome P450 2C8 (CYP2C8) DME0018
17alpha-Ethinylestradiol
Oxidation - 7-Hydroxylation Mestranol [2] , [3]
Cytochrome P450 2C9 (CYP2C9) DME0019
Ethinyl estradiol
Oxidation - 7-Hydroxylation Ethinyl estradiol [1]
Cytochrome P450 2C9 (CYP2C9) DME0019
17alpha-Ethinylestradiol
Oxidation - 7-Hydroxylation Mestranol [2] , [3]
Cytochrome P450 3A4 (CYP3A4) DME0001
Ethinyl estradiol
Oxidation - 7-Hydroxylation Ethinyl estradiol [1]
Cytochrome P450 3A4 (CYP3A4) DME0001
17alpha-Ethinylestradiol
Oxidation - 7-Hydroxylation Mestranol [2] , [3]
Cytochrome P450 3A5 (CYP3A5) DME0012
17alpha-Ethinylestradiol
Oxidation - 7-Hydroxylation Mestranol [2] , [3]
Cytochrome P450 3A7 (CYP3A7) DME0015
Ethinyl estradiol
Oxidation - 7-Hydroxylation Ethinyl estradiol [1]
DME(s) Metabolizing This DM
DME Name DME ID Product Reaction Related Drug REF
Catechol O-methyltransferase (COMT) DME0043
7-methoxyethinylestradiol
Conjugation - O-Methylation Ethinyl estradiol [2]
Monoamine oxidase type A (MAO-A) DME0044
7-methoxyethinylestradiol
Conjugation - O-Methylation Mestranol [2] , [3]
Full List of Drug(s) That Produce This DM By Metabolism
Ethinyl estradiol DR0656 Approved Menopausal disorder
Mestranol DR1034 Phase 4 Menorrhagia
References
1 Sulfotransferase 1E1 is a low km isoform mediating the 3-O-sulfation of ethinyl estradiol Drug Metab Dispos. 2004 Nov;32(11):1299-303. doi: 10.1124/dmd.32.11..
2 Genetic variation in the first-pass metabolism of ethinylestradiol, sex hormone binding globulin levels and venous thrombosis risk Eur J Intern Med. 2017 Jul;42:54-60. doi: 10.1016/j.ejim.2017.05.019.
3 Metabolism of 17 alpha-ethinylestradiol by human liver microsomes in vitro: aromatic hydroxylation and irreversible protein binding of metabolites J Clin Endocrinol Metab. 1974 Dec;39(6):1072-80. doi: 10.1210/jcem-39-6-1072.

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