Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME0015)
DME Name Cytochrome P450 3A7 (CYP3A7), Homo sapiens
Synonyms Cytochrome P450 family 3 subfamily A member 7; Cytochrome P450-HFLA; CYP3A7; CYPIIIA7; P450HLp2
Gene Name CYP3A7
UniProt ID
CP3A7_HUMAN
Gene ID
1551
EC Number    EC: 1.14.14.1     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
Flavin/flavoprotein donor oxidoreductase
EC: 1.14.14.1
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
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       Interactions between Microbiome and DME (MICBIO)                       
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       Interactions between Xenobiotics and DME (XEOTIC)                      
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Sequence
MDLIPNLAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNALSFRKGYWTF
DMECYKKYRKVWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKNAISI
AEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYS
MDVITSTSFGVSIDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTPILEALNITV
FPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSI
IFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVV
NETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFS
KKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRFG
GLLLTEKPIVLKAESRDETVSGA
Pathway Chemical carcinogenesis (hsa05204 )
Metabolic pathways (hsa01100 )
Retinol metabolism (hsa00830 )
Steroid hormone biosynthesis (hsa00140 )
Function This enzyme is involved in the metabolism of steroid hormones and vitamins during embryogenesis. It catalyzes the hydroxylation of carbon-hydrogen bonds and metabolizes 3beta- hydroxyandrost-5-en-17-one (dehydroepiandrosterone, DHEA) and exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1), particularly D- ring hydroxylated estrone at the C16-alpha position. It mainly hydroxylates all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may play a role in atRA clearance during fetal development. And it is also involved in the oxidative metabolism of xenobiotics including anticonvulsants.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:      101 Drugs
Cobicistat
 Drug Info Approved Human immunodeficiency virus infection ICD11: 1C60 [1]
Tamoxifen citrate
 Drug Info Approved Breast cancer ICD11: 2C60 [2]
Estradiol acetate
 Drug Info Approved Acquired prion disease ICD11: 8E01 [3]
Estradiol cypionate
 Drug Info Approved Acquired prion disease ICD11: 8E01 [4]
Estradiol valerate
 Drug Info Approved Acquired prion disease ICD11: 8E01 [2]
Estrone
 Drug Info Approved Menopausal disorder ICD11: GA30 [5]
Atazanavir
 Drug Info Approved Human immunodeficiency virus infection ICD11: 1C60 [6]
Cocaine
 Drug Info Approved Anaesthesia ICD11: 8E22 [2]
Daclatasvir dihydrochloride
 Drug Info Approved Viral hepatitis ICD11: 1E51 [7]
Delavirdine mesylate
 Drug Info Approved Human immunodeficiency virus infection ICD11: 1C60 [2]
Progesterone
 Drug Info Approved Premature labour ICD11: JB00 [8]
Imatinib mesylate
 Drug Info Approved Chronic myelogenous leukaemia ICD11: 2A20 [2]
Lidocaine
 Drug Info Approved Anaesthesia ICD11: 8E22 [2]
Metronidazole
 Drug Info Approved Amebiasis ICD11: 1A36 [9]
Temsirolimus
 Drug Info Approved Renal cell carcinoma ICD11: 2C90 [2]
Ciclosporin
 Drug Info Approved Viral hepatitis ICD11: 1E51 [10]
Ifosfamide
 Drug Info Approved Lung cancer ICD11: 2C25 [11]
Sunitinib malate
 Drug Info Approved Renal cell carcinoma ICD11: 2C90 [2]
Tretinoin
 Drug Info Approved Acne vulgaris ICD11: ED80 [12]
Oxycodone hydrochloride
 Drug Info Approved Anaesthesia ICD11: 8E22 [13]
Sirolimus
 Drug Info Approved Lymphangioleiomyomatosis ICD11: CB07 [2]
Beclomethasone dipropionate
 Drug Info Approved Allergic rhinitis ICD11: CA08 [14], [15]
Beclomethasone dipropionate
 Drug Info Approved Allergic rhinitis ICD11: CA08 [16]
Dehydroepiandrosterone
 Drug Info Approved Dyspareunia ICD11: GA12 [11]
Deoxycholic acid
 Drug Info Approved Obesity ICD11: 5B81 [17]
Hydrocortisone
 Drug Info Approved Uncontrolled gout ICD11: FA25 [18]
Indinavir sulfate
 Drug Info Approved Human immunodeficiency virus infection ICD11: 1C60 [19]
Quinine sulfate
 Drug Info Approved Malaria ICD11: 1F40 [2]
Alfentanil
 Drug Info Approved Anaesthesia ICD11: 8E22 [2]
Cisapride
 Drug Info Approved Gastro-oesophageal reflux disease ICD11: DA22 [20]
Dextromethorphan hydrobromide
 Drug Info Approved Atherosclerosis ICD11: BA80 [21]
Diazepam
 Drug Info Approved Epilepsy ICD11: 8A60 [2]
Diphenylpyraline
 Drug Info Approved Allergy ICD11: 4A80 [22]
Estriol
 Drug Info Approved Menopausal disorder ICD11: GA30 [23]
Finasteride
 Drug Info Approved Prostatic hyperplasia ICD11: GA90 [2]
Haloperidol decanoate
 Drug Info Approved Agitation/aggression ICD11: 6D86 [2]
Nateglinide
 Drug Info Approved Diabetes mellitus ICD11: 5A10 [2]
Nevirapine
 Drug Info Approved Human immunodeficiency virus infection ICD11: 1C60 [24]
Norethindrone acetate
 Drug Info Approved Menorrhagia ICD11: GA20 [25]
Ondansetron
 Drug Info Approved Gastritis ICD11: DA42 [26]
Propranolol hydrochloride
 Drug Info Approved Migraine ICD11: 8A80 [27]
Trazodone hydrochloride
 Drug Info Approved Depression ICD11: 6A71 [2]
Verapamil hydrochloride
 Drug Info Approved Essential hypertension ICD11: BA00 [28]
Buspirone
 Drug Info Approved Anxiety disorder ICD11: 6B00 [2]
Carbamazepine
 Drug Info Approved Epilepsy ICD11: 8A60 [29]
Codeine
 Drug Info Approved Anaesthesia ICD11: 8E22 [11]
Cortisone acetate
 Drug Info Approved Prostate cancer ICD11: 2C82 [30]
Cyclophosphamide
 Drug Info Approved Multiple myeloma ICD11: 2A83 [11]
Diltiazem hydrochloride
 Drug Info Approved Essential hypertension ICD11: BA00 [31]
Felbamate
 Drug Info Approved Epilepsy ICD11: 8A60 [32]
Imipramine hydrochloride
 Drug Info Approved Depression ICD11: 6A71 [33]
Midazolam hydrochloride
 Drug Info Approved Anxiety disorder ICD11: 6B00 [11]
Phenytoin
 Drug Info Approved Epilepsy ICD11: 8A60 [34]
Quinidine
 Drug Info Approved Ventricular tachyarrhythmia ICD11: BC71 [2]
Zolpidem tartrate
 Drug Info Approved Insomnia ICD11: 7A00 [35]
Atorvastatin calcium
 Drug Info Approved Dyslipidaemia ICD11: 5C81 [36]
Buprenorphine hydrochloride
 Drug Info Approved Anaesthesia ICD11: 8E22 [37]
Fentanyl citrate
 Drug Info Approved Anaesthesia ICD11: 8E22 [2]
Nisoldipine
 Drug Info Approved Essential hypertension ICD11: BA00 [2]
Pimozide
 Drug Info Approved Schizophrenia ICD11: 6A20 [2]
Quetiapine fumarate
 Drug Info Approved Schizophrenia ICD11: 6A20 [38]
Ritonavir
 Drug Info Approved Human immunodeficiency virus infection ICD11: 1C60 [39]
Saquinavir mesylate
 Drug Info Approved Human immunodeficiency virus infection ICD11: 1C60 [19]
Testosterone undecanoate
 Drug Info Approved Hypogonadism ICD11: 5A61 [18]
Triazolam
 Drug Info Approved Insomnia ICD11: 7A00 [2]
Alprazolam
 Drug Info Approved Anxiety disorder ICD11: 6B00 [2]
Aripiprazole lauroxil
 Drug Info Approved Schizophrenia ICD11: 6A20 [2]
Chlorpheniramine
 Drug Info Approved Allergic rhinitis ICD11: CA08 [2]
Docetaxel
 Drug Info Approved Breast cancer ICD11: 2C60 [2]
Iloperidone
 Drug Info Approved Schizophrenia ICD11: 6A20 [40]
Irinotecan hydrochloride
 Drug Info Approved Colon cancer ICD11: 2B90 [2]
Levomethadyl acetate hydrochloride
 Drug Info Approved Opiate dependence ICD11: 6C43 [2]
Methadone
 Drug Info Approved Anaesthesia ICD11: 8E22 [41]
Nelfinavir mesylate
 Drug Info Approved Human immunodeficiency virus infection ICD11: 1C60 [19]
Paclitaxel
 Drug Info Approved Ovarian cancer ICD11: 2C73 [2]
Phenobarbital
 Drug Info Approved Epilepsy ICD11: 8A60 [42]
Sorafenib
 Drug Info Approved Renal cell carcinoma ICD11: 2C90 [2]
Zaleplon
 Drug Info Approved Insomnia ICD11: 7A00 [2]
Cerivastatin sodium
 Drug Info Approved Hypertriglyceridaemia ICD11: 5C80 [2]
Cilostazol
 Drug Info Approved Arteriosclerosis obliterans ICD11: BD40 [43]
Dapsone
 Drug Info Approved Pneumocystis pneumonia ICD11: CA40 [2]
Levomethadyl Acetate
 Drug Info Approved Opiate dependence ICD11: 6C43 [44]
Oxazepam
 Drug Info Approved Anxiety disorder ICD11: 6B00 [45]
Salmeterol xinafoate
 Drug Info Approved Asthma ICD11: CA23 [2]
Sildenafil citrate
 Drug Info Approved Erectile dysfunction ICD11: HA01 [2]
Zonisamide
 Drug Info Approved Epilepsy ICD11: 8A60 [46]
Aztreonam
 Drug Info Approved Cystic fibrosis ICD11: CA25 [47]
Erythromycin stearate
 Drug Info Approved Acute upper respiratory infection ICD11: CA07 [24]
Fluticasone furoate
 Drug Info Approved Allergic rhinitis ICD11: CA08 [48]
Fluticasone propionate
 Drug Info Approved Asthma ICD11: CA23 [48]
Fluticasone propionate
 Drug Info Approved Asthma ICD11: CA23 [49]
Lorlatinib
 Drug Info Approved Lung cancer ICD11: 2C25 [50]
Praziquantel
 Drug Info Approved Schistosomiasis ICD11: 1F86 [51]
Risdiplam
 Drug Info Approved Muscular atrophy ICD11: 8B61 [52]
Tadalafil
 Drug Info Approved Erectile dysfunction ICD11: HA01 [53]
Testosterone cypionate
 Drug Info Approved Testosterone deficiency ICD11: 5A81 [18]
Testosterone enanthate
 Drug Info Approved Testosterone deficiency ICD11: 5A81 [18]
Triamcinolone diacetate
 Drug Info Approved Allergy ICD11: 4A80 [54]
Vincristine sulfate
 Drug Info Approved Acute lymphoblastic leukemia ICD11: 2B33 [2]
Zalcitabine
 Drug Info Approved Human immunodeficiency virus infection ICD11: 1C60 [55]
Dexamethasone acetate
 Drug Info Approved Rheumatoid arthritis ICD11: FA20 [56]
      Drugs in Phase 4 Clinical Trial Click to Show/Hide the Full List of Drugs:          8 Drugs
Glibenclamide
 Drug Info Phase 4 Diabetes mellitus ICD11: 5A10 [57]
Astemizole
 Drug Info Phase 4 Allergic rhinitis ICD11: CA08 [2]
Terfenadine
 Drug Info Phase 4 Allergy ICD11: 4A80 [2]
Aminophenazone
 Drug Info Phase 4 Anaesthesia ICD11: 8E22 [11]
Chlorphenamine
 Drug Info Phase 4 Allergy ICD11: 4A80 [2]
Flucloxacillin
 Drug Info Phase 4 Staphylococcus infection ICD11: 1B73 [58]
Prasterone sulfate
 Drug Info Phase 4 Adrenocortical deficiency ICD11: 5A74 [59]
Clotiapine
 Drug Info Phase 4 Schizophrenia ICD11: 6A20 [60]
      Drugs in Phase 3 Clinical Trial Click to Show/Hide the Full List of Drugs:          8 Drugs
E-3A
 Drug Info Phase 3 Turner syndrome ICD11: LD50 [2]
KW-5338
 Drug Info Phase 3 Gastroparesis ICD11: DA41 [2]
NSC-122758
 Drug Info Phase 3 Vitamin deficiency ICD11: 5B55 [12]
NSC-122758
 Drug Info Phase 3 Vitamin deficiency ICD11: 5B55 [12], [61]
BRN-0077922
 Drug Info Phase 3 Influenza virus infection ICD11: 1E30 [62]
DUP-996
 Drug Info Phase 3 Cognitive impairment ICD11: 6D71 [63]
RO-7-0207
 Drug Info Phase 3 Colon cancer ICD11: 2B90 [64]
Sildenafil
 Drug Info Phase 3 Erectile dysfunction ICD11: HA00-HA01 [53]
      Drugs in Phase 2 Clinical Trial Click to Show/Hide the Full List of Drugs:          2 Drugs
Lilly-112531
 Drug Info Phase 2/3 Diffuse large B-cell lymphoma ICD11: 2A81 [65]
RG-7916
 Drug Info Phase 2 Muscular atrophy ICD11: 8B61
      Drugs in Phase 1 Clinical Trial Click to Show/Hide the Full List of Drugs:          3 Drugs
TJN-324
 Drug Info Phase 1/2 Essential hypertension ICD11: BA00 [2]
Benzoylphenylurea
 Drug Info Phase 1 Solid tumour/cancer ICD11: 2A00-2F9Z [66], [67]
BRN-0498823
 Drug Info Phase 1 Essential hypertension ICD11: BA00 [2]
      Discontinued/withdrawn Drugs Click to Show/Hide the Full List of Drugs:        11 Drugs
Napitane mesilate
 Drug Info Discontinued in Phase 2 Major depressive disorder ICD11: 6A70-6A7Z [68]
Lexacalcitol
 Drug Info Discontinued in Phase 2 Solid tumour/cancer ICD11: 2A00-2F9Z [68]
NB-506
 Drug Info Discontinued in Phase 2 Solid tumour/cancer ICD11: 2A00-2F9Z [68]
Perillyl alcohol
 Drug Info Discontinued in Phase 2 Solid tumour/cancer ICD11: 2A00-2F9Z [68]
R-ketoprofen
 Drug Info Discontinued in Phase 2 Discovery agent ICD: N.A. [68]
TAK-802
 Drug Info Discontinued in Phase 2 Urinary dysfunction ICD11: GC2Z [68]
BMS-181168
 Drug Info Discontinued in Phase 2 Cognitive impairment ICD11: 6D71 [68]
AOD-9604
 Drug Info Discontinued in Phase 2 Obesity ICD11: 5B80-5B81 [68]
CPA-926
 Drug Info Discontinued in Phase 2 Rheumatoid arthritis ICD11: FA20 [68]
Lodenosine
 Drug Info Discontinued in Phase 2 Human immunodeficiency virus infection ICD11: 1C60-1C62 [68]
T-1095
 Drug Info Discontinued in Phase 2 Diabetic complication ICD11: 5A2Y [68]
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          2 Drugs
Ethylmorphine
 Drug Info Investigative Discovery agent ICD: N.A. [11]
Erythromycin salnacedin
 Drug Info Investigative Discovery agent ICD: N.A. [24]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR003199 Barnidipine Barnidipine metabolite M-1 Oxidation - N-Debenzylization Barnidipine [69]
MR003200 Barnidipine Barnidipine metabolite M-8 Oxidation - Oxidation Barnidipine [69]
MR003190 Barnidipine metabolite M-1 Barnidipine metabolite M-3 Hydrolysis - Hydrolysis Barnidipine [69]
MR003193 Barnidipine metabolite M-3 Barnidipine metabolite M-4 Oxidation - Oxidation Barnidipine [69]
MR003198 Barnidipine metabolite M-8 Barnidipine metabolite M-2 Oxidation - N-Debenzylization Barnidipine [69]
MR009246 Beclomethasone dipropionate Beclomethasone-17-monopropionate (17-BMP) Hydrolysis - Hydrolysis Beclomethasone dipropionate [70]
MR009251 Beclomethasone dipropionate Beclomethasone-21-monopropionate (21-BMP) Hydrolysis - Hydrolysis Beclomethasone dipropionate [16]
MR009253 Beclomethasone dipropionate 6beta-OH-BDP Unclear - Unclear Beclomethasone dipropionate [71]
MR009254 Beclomethasone dipropionate Delta6-BDP Unclear - Unclear Beclomethasone dipropionate [71]
MR010376 Benzoylphenylurea MmBPU Oxidation - Desmethylation Benzoylphenylurea [66], [67]
MR000491 Bupivacaine hydrochloride Hydroxybuprenorphine Oxidation - Hydroxylation Buprenorphine hydrochloride [72]
MR012897 Cyclobenzaprine 4-Hydroxycyclophosphamide Oxidation - 4-hydroxylation Cyclobenzaprine [73], [37]
MR012907 Cyclobenzaprine Dechloroethyl cyclophosphamide Unclear - Unclear Cyclobenzaprine [74]
MR012908 Cyclobenzaprine Chloroacetaldehyde Unclear - Unclear Cyclobenzaprine [74]
MR013673 Deoxycholic acid 1beta-OH-DCA Unclear - Unclear Deoxycholic acid [17]
MR000891 Docetaxel . Unclear - Unclear Docetaxel [75]
MR002696 Estrone 2-hydroxyestrone Oxidation - Hydroxylation Estrone [76]
MR002701 Estrone 4-OH-estrone Oxidation - Hydroxylation Estrone [77]
MR002706 Estrone 16alpha-OH-estrone Oxidation - Hydroxylation Estrone [77]
MR002702 Estrone 6alpha-OH-estrone Oxidation - Hydroxylation Estrone [77]
MR002707 Estrone 16beta-OH-estrone Oxidation - Hydroxylation Estrone [77]
MR002703 Estrone 6beta-estrone Unclear - Unclear Estrone [77]
MR002705 Estrone 15alpha-OH-estrone Unclear - Unclear Estrone [77]
MR002721 Ethinyl estradiol 2-hydroxyethinylestradiol Oxidation - 2-Hydroxylation Ethinyl estradiol [78]
MR002722 Ethinyl estradiol 4-hydroxyethinylestradiol Oxidation - 4-Hydroxylation Ethinyl estradiol [78]
MR002723 Ethinyl estradiol 6-hydroxyethinylestradiol Oxidation - 6-Hydroxylation Ethinyl estradiol [78]
MR002724 Ethinyl estradiol 7-hydroxyethinylestradiol Oxidation - 7-Hydroxylation Ethinyl estradiol [78]
MR002725 Ethinyl estradiol 16alpha-hydroxyethinylestradiol Oxidation - 16-Hydroxylation Ethinyl estradiol [78]
MR001019 Felbamate p-hydroxyfelbamate Unclear - Unclear Felbamate [32]
MR001020 Felbamate 2-hydroxyfelbamate Oxidation - Oxidation Felbamate [79]
MR001025 Fentanyl citrate . Unclear - Unclear Fentanyl citrate [75]
MR001038 Finasteride . Unclear - Unclear Finasteride [75]
MR007190 Flucloxacillin 5-hydroxymethyl-flucloxacillin Oxidation - Oxidationn Flucloxacillin [58]
MR005057 Fluticasone propionate Fluticasone 17beta-carboxylic acid Unclear - Unclear Fluticasone propionate [80]
MR007218 Glibenclamide 2-trans-hydroxycyclohexyl glyburide Oxidation - Aliphatic hydroxylation Glibenclamide [81], [57]
MR007219 Glibenclamide 4-cis-hydroxycyclohexyl glyburide Oxidation - Aliphatic hydroxylation Glibenclamide [81], [57]
MR007220 Glibenclamide 3-trans-Hydroxycyclohexyl glyburide Oxidation - Aliphatic hydroxylation Glibenclamide [81], [57]
MR007221 Glibenclamide Ethylhydroxycyclohexyl glyburide Oxidation - Aliphatic hydroxylation Glibenclamide [81], [57]
MR007219 Glibenclamide 4-trans-hydroxycyclohexyl glyburide Oxidation - Aliphatic hydroxylation Glibenclamide [81], [57], [82]
MR007222 Glibenclamide 3-cis-Hydroxycyclohexyl glyburide Oxidation - Aliphatic hydroxylation Glibenclamide [81], [57], [82]
MR004650 Ifosfamide 4-Hydroxyifosfamide Oxidation - 4-hydroxylation Ifosfamide [73]
MR004662 Ifosfamide 3-Dechloroethylifosfamide Unclear - Unclear Ifosfamide [83], [73]
MR004663 Ifosfamide Dechloroethylifosfamide Unclear - Unclear Ifosfamide [73]
MR008028 Levomethadyl Acetate Nor-levomethadyl acetate (nor-LAAM) Oxidation - N-demethylation Levomethadyl Acetate [73], [44]
MR008029 Nor-levomethadyl acetate (nor-LAAM) Dinor-levomethadyl acetate Unclear - Unclear Levomethadyl Acetate [73]
MR003114 Levomethadyl acetate hydrochloride . Unclear - Unclear Levomethadyl acetate hydrochloride [75]
MR001552 Lidocaine 3-hydroxylidocaine Oxidation - Hydroxylation Lidocaine [84]
MR006058 Lilly-112531 Vindesine N-oxide Oxidation - N-oxidation Lilly-112531 [85]
MR009998 Methadone EDDP Oxidation - N-demethylation Methadone [41], [86]
MR004727 Metronidazole 2-hydroxymetronidazole Oxidation - Hydrolyzationn Metronidazole [9], [87], [88], [89]
MR006380 NSC-122758 4-Hydroxyretinoic acid Oxidation - 4-hydroxylation NSC-122758 [12]
MR006383 NSC-122758 4-Oxoretinoic acid Unclear - Unclear NSC-122758 [12]
MR001878 Noroxycodone Noroxymorphone Oxidation - N-Demethylation Oxycodone hydrochloride [90], [91]
MR001881 Oxycodone hydrochloride Noroxycodone Oxidation - N-Demethylation Oxycodone hydrochloride [90], [91], [92]
MR001886 Oxymorphone Noroxymorphone Oxidation - N-Demethylation Oxycodone hydrochloride [93]
MR002023 Phenobarbital 4-hydroxyphenobarbital Oxidation - 4-Hydroxylation Phenobarbital [37]
MR002024 Phenobarbital Mephobarbital Conjugation - Methylation Phenobarbital [94]
MR002030 Hydroxyphenytoin Phenytoin catechol Oxidation - Oxidation Phenytoin [83]
MR005804 Prasterone sulfate Unclear Unclear - Unclear Prasterone sulfate [59]
MR005593 Risdiplam Risdiplam M1 metabolite Oxidation - N-hydroxylation Risdiplam [52]
MR006437 RO-7-0207 (2S,3S,4S,5R)-6-[1-chloro-3-(2-methyl-5-nitroimidazol-1-yl)propan-2-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Unclear - Unclear RO-7-0207 [64]
MR002221 Salmeterol xinafoate Alpha-hydroxysalmeterol Oxidation - Hydroxylation Salmeterol xinafoate [95], [96], [97]
MR002885 Saquinavir mesylate M2 di-hydroxylated metabolite Oxidation - Hydroxylation Saquinavir mesylate [98], [19], [99]
MR013895 Sildenafil N-desmethyl Sildenafil Unclear - Unclear Sildenafil [100], [101], [53]
MR006834 Sorafenib Pyridine N-oxide glucuronide Multi-steps Reaction - Oxidationn; glucuronidation Sorafenib [83], [102]
MR006833 Sorafenib Pyridostigmine Oxidation - Oxidationn Sorafenib [83]
MR002329 Tadalafil Tadalafil catechol Oxidation - Oxidation Tadalafil [103], [53]
MR002388 Temsirolimus . Unclear - Unclear Temsirolimus [75]
MR009627 4-Hydroxyretinoic acid 4-Oxoretinoic acid Oxidation - Oxidation Tretinoin [12], [104]
MR009636 Tretinoin 18-OH-RA Oxidation - Hydroxylation Tretinoin [12], [104], [105]
MR009626 Tretinoin 4-Hydroxyretinoic acid Oxidation - 4-hydroxylation Tretinoin [12], [105]
MR009631 Tretinoin 13-cis RA Other reaction - Isomerization Tretinoin [105], [104]
MR002449 Triamcinolone diacetate 6-beta-hydroxy-triamcinolone Oxidation - 6-Beta-Hydroxylation Triamcinolone diacetate [106], [107], [54]
MR002460 Trimethoprim Calpha-OH-TMP Oxidation - C-Oxidation Trimethoprim [108]
⏷ Show the Full List of 74 MR(s)
References
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2 Drug Interactions Flockhart Table
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4 A potential role for the estrogen-metabolizing cytochrome P450 enzymes in human breast carcinogenesis. Breast Cancer Res Treat. 2003 Dec;82(3):191-7.
5 DrugBank(Pharmacology-Metabolism)Estrone
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7 Daclatasvir: a NS5A replication complex inhibitor for hepatitis C infection. Ann Pharmacother. 2016 Jan;50(1):39-46.
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12 Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites. Mol Pharmacol. 2000 Dec;58(6):1341-8.
13 Human Fetal Liver Metabolism of Oxycodone Is Mediated by CYP3A7
14 Activation of beclomethasone dipropionate by hydrolysis to beclomethasone-17-monopropionate
15 Degradation products of beclomethasone dipropionate in human plasma
16 Comparative kinetics of metabolism of beclomethasone propionate esters in human lung homogenates and plasma
17 CYP3A Specifically Catalyzes 1-Hydroxylation of Deoxycholic Acid: Characterization and Enzymatic Synthesis of a Potential Novel Urinary Biomarker for CYP3A Activity
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19 Differential inhibition of cytochrome P450 3A4, 3A5 and 3A7 by five human immunodeficiency virus (HIV) protease inhibitors in vitro. Basic Clin Pharmacol Toxicol. 2006 Jan;98(1):79-85.
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21 Characterization of dextromethorphan N-demethylation by human liver microsomes. Contribution of the cytochrome P450 3A (CYP3A) subfamily. Biochem Pharmacol. 1994 Jul 5;48(1):173-82.
22 Drug Interactions Flockhart Table:Fentanyl citrate
23 Expression and cyclic variability of CYP3A4 and CYP3A7 isoforms in human endometrium and cervix during the menstrual cycle. Drug Metab Dispos. 2003 Jan;31(1):1-6.
24 Helices F-G are important for the substrate specificities of CYP3A7. Drug Metab Dispos. 2007 Mar;35(3):484-92.
25 The interaction between St John's wort and an oral contraceptive. Clin Pharmacol Ther. 2003 Dec;74(6):525-35.
26 Multiple forms of cytochrome P450 are involved in the metabolism of ondansetron in humans. Drug Metab Dispos. 1995 Nov;23(11):1225-30.
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28 Prediction of cytochrome P450 3A inhibition by verapamil enantiomers and their metabolites. Drug Metab Dispos. 2004 Feb;32(2):259-66.
29 CYP3A4 and CYP3A7-mediated carbamazepine 10,11-epoxidation are activated by differential endogenous steroids. Drug Metab Dispos. 2003 Apr;31(4):432-8.
30 Comparative pharmacokinetics and metabolism studies in lean and diet- induced obese mice: an animal efficacy model for 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) inhibitors. Drug Metab Lett. 2011 Jan;5(1):55-63.
31 FDA Drug Development and Drug Interactions
32 DrugBank(Pharmacology-Metabolism)Felbamate
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34 PharmGKB summary: phenytoin pathway. Pharmacogenet Genomics. 2012 Jun;22(6):466-70.
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38 A liquid chromatographic-electrospray-tandem mass spectrometric method for quantitation of quetiapine in human plasma and liver microsomes: application to study in vitro metabolism. J Anal Toxicol. 2004 Sep;28(6):443-8.
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40 Application of liquid chromatography/mass spectrometry in accelerating the identification of human liver cytochrome P450 isoforms involved in the metabolism of iloperidone. J Pharmacol Exp Ther. 1998 Sep;286(3):1285-93.
41 Methadone metabolism and drug-drug interactions: in vitro and in vivo literature review. J Pharm Sci. 2018 Dec;107(12):2983-2991.
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48 Biotransformation of fluticasone: in vitro characterization. Drug Metab Dispos. 2006 Jun;34(6):1035-40.
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50 Product characteristics of Lorviqua.
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52 Estimation of FMO3 Ontogeny by Mechanistic Population Pharmacokinetic Modelling of Risdiplam and Its Impact on Drug-Drug Interactions in Children
53 Contribution of CYP3A isoforms to dealkylation of PDE5 inhibitors: a comparison between sildenafil N-demethylation and tadalafil demethylenation. Biol Pharm Bull. 2015;38(1):58-65.
54 Metabolic pathways of inhaled glucocorticoids by the CYP3A enzymes. Drug Metab Dispos. 2013 Feb;41(2):379-89.
55 Protease inhibitors in patients with HIV disease. Clinically important pharmacokinetic considerations. Clin Pharmacokinet. 1997 Mar;32(3):194-209.
56 Cytotoxicity of chloroacetanilide herbicide alachlor in HepG2 cells independent of CYP3A4 and CYP3A7. Food Chem Toxicol. 2007 May;45(5):871-7.
57 Identification of CYP3A7 for glyburide metabolism in human fetal livers. Biochem Pharmacol. 2014 Dec 15;92(4):690-700.
58 Characterization of kinetics of human cytochrome P450s involved in bioactivation of flucloxacillin: inhibition of CYP3A-catalysed hydroxylation by sulfaphenazole. Br J Pharmacol. 2019 Feb;176(3):466-477.
59 CYP3A7*1C polymorphism, serum dehydroepiandrosterone sulfate level, and bone mineral density in postmenopausal women. Calcif Tissue Int. 2007 Mar;80(3):154-9.
60 Biotransformation of post-clozapine antipsychotics: pharmacological implications. Clin Pharmacokinet. 2000 May;38(5):393-414.
61 CYP26C1 is a hydroxylase of multiple active retinoids and interacts with cellular retinoic acid binding proteins. Mol Pharmacol. 2018 May;93(5):489-503.
62 Effect of glycyrrhizin on the activity of CYP3A enzyme in humans. Eur J Clin Pharmacol. 2010 Aug;66(8):805-810.
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64 Effect of ketoconazole on the pharmacokinetics of ornidazole--a possible role of p-glycoprotein and CYP3A. Drug Metabol Drug Interact. 2006;22(1):67-77.
65 Structural perspectives of the CYP3A family and their small molecule modulators in drug metabolism. 2019, 3(3), 132-142.
66 In vitro and in vivo clinical pharmacology of dimethyl benzoylphenylurea, a novel oral tubulin-interactive agent
67 Phase I study of continuous weekly dosing of dimethylamino benzoylphenylurea (BPU) in patients with solid tumours
68 Identification of Selective CYP3A7 and CYP3A4 Substrates and Inhibitors Using a High-Throughput Screening Platform. Front Pharmacol. 2022 Jul 1;13:899536. doi: 10.3389/fphar.2022.899536.
69 Examination of metabolic pathways and identification of human liver cytochrome P450 isozymes responsible for the metabolism of barnidipine, a calcium channel blocker. Xenobiotica. 1997 Sep;27(9):885-900.
70 DrugBank(Pharmacology-Metabolism):Beclomethasone dipropionate
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72 In vitro metabolism study of buprenorphine: evidence for new metabolic pathways. Drug Metab Dispos. 2005 May;33(5):689-95.
73 The KEGG resource for deciphering the genome
74 U. S. FDA Label -Cyclobenzaprine
75 Drug Interactions Flockhart Table:Docetaxel
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78 Sulfotransferase 1E1 is a low km isoform mediating the 3-O-sulfation of ethinyl estradiol Drug Metab Dispos. 2004 Nov;32(11):1299-303. doi: 10.1124/dmd.32.11..
79 LABEL:FELBAMATE suspension
80 DrugBank(Pharmacology-Metabolism):Fluticasone propionate
81 Kinetics of glyburide metabolism by hepatic and placental microsomes of human and baboon
82 Identification of glyburide metabolites formed by hepatic and placental microsomes of humans and baboons
83 Pharmacogenomics knowledge for personalized medicine Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96.
84 The Use and Method of Action of Intravenous Lidocaine and Its Metabolite in Headache Disorders Headache. 2018 May;58(5):783-789. doi: 10.1111/head.13298.
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86 Effects of cytochrome P450 single nucleotide polymorphisms on methadone metabolism and pharmacodynamics
87 Disposition and metabolism of metronidazole in patients with liver failure
88 Metronidazole Metabolism in Neonates and the Interplay Between Ontogeny and Genetic Variation
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90 Quantitative contribution of CYP2D6 and CYP3A to oxycodone metabolism in human liver and intestinal microsomes. Drug Metab Dispos. 2004 Apr;32(4):447-54.
91 Enzalutamide Reduces Oxycodone Exposure in Men with Prostate Cancer. Clin Pharmacokinet. 2023 May 10. doi: 10.1007/s40262-023-01255-1.
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93 DrugBank(Pharmacology-Metabolism)Oxycodone hydrochloride
94 DrugBank(Pharmacology-Metabolism)Phenobarbital
95 Determination of salmeterol, -hydroxysalmeterol and fluticasone propionate in human urine and plasma for doping control using UHPLC-QTOF-MS. Biomed Chromatogr. 2021 Aug;35(8):e5114. doi: 10.1002/bmc.5114.
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97 The salmeterol anomaly and the need for a urine threshold. Drug Test Anal. 2022 Jun;14(6):997-1003. doi: 10.1002/dta.2810.
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100 Functional Measurement of CYP2C9 and CYP3A4 Allelic Polymorphism on Sildenafil Metabolism
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102 Interaction of sorafenib and cytochrome P450 isoenzymes in patients with advanced melanoma: a phase I/II pharmacokinetic interaction study. Cancer Chemother Pharmacol. 2011 Nov;68(5):1111-8.
103 Effect of Ticagrelor, a Cytochrome P450 3A4 Inhibitor, on the Pharmacokinetics of Tadalafil in Rats Pharmaceutics. 2019 Jul 20;11(7):354. doi: 10.3390/pharmaceutics11070354.
104 Retinoic acid metabolism and mechanism of action: a review
105 Human cytochrome P450s involved in the metabolism of 9-cis- and 13-cis-retinoic acids
106 A mass balance study to evaluate the biotransformation and excretion of [14C]-triamcinolone acetonide following oral administration J Clin Pharmacol. 2000 Jul;40(7):770-80. doi: 10.1177/00912700022009413.
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