| General Information of Drug Metabolite (DM) (ID: DM000860) |
| DM Name |
3-N-acetylamifampridine
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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N-acetyltransferase 1 (NAT1)
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DME0050
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| Conjugation - Acetylation |
Amifampridine
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[1] , [2] |
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N-acetyltransferase 2 (NAT2)
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DME0051
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| Conjugation - Acetylation |
Amifampridine
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[1] , [2] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| Amifampridine |
DR1747
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Approved |
Lambert-Eaton syndrome |
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| References |
| 1 |
Genetic variation in aryl N-acetyltransferase results in significant differences in the pharmacokinetic and safety profiles of amifampridine (3,4-diaminopyridine) phosphate. Pharmacol Res Perspect. 2015 Feb;3(1):e00099.
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| 2 |
Investigation of N-Acetyltransferase 2-Mediated Drug Interactions of Amifampridine: In Vitro and In Vivo Evidence of Drug Interactions with Acetaminophen. Pharmaceutics. 2023 May 11;15(5):1471. doi: 10.3390/pharmaceutics15051471.
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