Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM001613)
DM Name	Barnidipine metabolite M-2

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Cytochrome P450 3A4 (CYP3A4)	DME0001	Barnidipine metabolite M-8	Oxidation - N-Debenzylization	Barnidipine	[1]
Cytochrome P450 3A43 (CYP3A43)	DME0022	Barnidipine metabolite M-8	Oxidation - N-Debenzylization	Barnidipine	[1]
Cytochrome P450 3A5 (CYP3A5)	DME0012	Barnidipine metabolite M-8	Oxidation - N-Debenzylization	Barnidipine	[1]
Cytochrome P450 3A7 (CYP3A7)	DME0015	Barnidipine metabolite M-8	Oxidation - N-Debenzylization	Barnidipine	[1]

Full List of Drug(s) That Produce This DM By Metabolism
Barnidipine		DR0175	Phase 4		Essential hypertension

References
1	Examination of metabolic pathways and identification of human liver cytochrome P450 isozymes responsible for the metabolism of barnidipine, a calcium channel blocker. Xenobiotica. 1997 Sep;27(9):885-900.

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