Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR0784)
Drug Name
Glycerol
Synonyms
Glicerina [DCIT]; Glycerin (mist); Glycerin mist; Glycerin, anhydrous; Glycerin, synthetic; Glycerine; Glycerine mist; Glycerinum; Glyceritol; Glycerolum; Glycyl alcohol; Glyrol; Glysanin; Grocolene; Incorporation factor; Ophthalgan; Bulbold; Citifluor AF 2; Cristal; Dagralax; Osmoglyn; PROPANE-1,2,3-TRIOL; Polyglycerine; Polyglycerol; Propanetriol; Synthetic glycerin; Synthetic glycerine; Trihydroxypropane; Vitrosupos; glycerin; glycerol; 1,2,3-Propanetriol; 1,2,3-trihydroxypropane; 56-81-5; 90 Technical glycerine; Moon; Optim; Star
Indication Hepatic encephalopathy [ICD11: DB99] Approved [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 92.09 Topological Polar Surface Area 60.7
Heavy Atom Count 6 Rotatable Bond Count 2
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 3
Cross-matching ID
PubChem CID
753
PubChem SID
2769 ; 3416 ; 74749 ; 583876 ; 584203 ; 584266 ; 584696 ; 585448 ; 585451 ; 585453 ; 585454 ; 585524 ; 585792 ; 587705 ; 819907 ; 819918 ; 819922 ; 820814 ; 821861 ; 822492 ; 823433 ; 823466 ; 823687 ; 823740 ; 823748 ; 823782 ; 823845 ; 824038 ; 824284 ; 826015 ; 826368 ; 826480 ; 826481 ; 826823 ; 827123 ; 827127 ; 827128 ; 827209 ; 827729 ; 829147 ; 829274 ; 829278 ; 829808 ; 829809 ; 829817 ; 830035 ; 830419 ; 830828 ; 831971 ; 831974
ChEBI ID
CHEBI:17754
CAS Number
611168-24-2
TTD Drug ID
D0E0BD
Formula
C3H8O3
Canonical SMILES
C(C(CO)O)O
InChI
1S/C3H8O3/c4-1-3(6)2-5/h3-6H,1-2H2
InChIKey
PEDCQBHIVMGVHV-UHFFFAOYSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Glycerophosphoric acid DM002134
754
Unclear 1 [3] , [5]
Dihydroxyacetone phosphate DM002135
668
Unclear 2 [6]
D-glyceraldehyde-3-P DM002136
439168
Unclear 3 [7]
Pyruvic acid DM002137
1060
Unclear 4 [6]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR001150 Glycerol Glycerol-3-phosphate Unclear GK [3], [5]
MR001147 Glycerol-3-phosphate Dihydroxyacetone phosphate Unclear Unclear [6]
MR001148 Dihydroxyacetone phosphate Glyceral-dehyde-3-phosphate Unclear Unclear [7]
MR001149 Glyceral-dehyde-3-phosphate Pyruvic acid Unclear Unclear [6]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Aquaporin adipose (AQP7) DME0407 Homo sapiens
AQP7_HUMAN
3.1.1.-
[2]
Glycerol kinase (GK) DMEN049 Homo sapiens
GLPK_HUMAN
3.5.2.2
[3]
Propanediol dehydrogenase (dhaT) DME1058 Lactobacillus brevis
A0A0C1Q6R1_LACBR
1.1.1.202
[4]
References
1 Glycerol was approved by FDA. The 2020 official website of the U.S. Food and Drug Administration.
2 Aquaporins in the human testis and spermatozoa - identification, involvement in sperm volume regulation and clinical relevance. Int J Androl. 2010 Aug 1;33(4):629-41.
3 The common metabolite glycerol-3-phosphate is a novel regulator of plant defense signaling Plant Signal Behav. 2009 Aug;4(8):746-9. doi: 10.4161/psb.4.8.9111.
4 Expression and characterization of a novel 1,3-propanediol dehydrogenase from Lactobacillus brevis. Appl Biochem Biotechnol. 2016 Jul;179(6):959-72.
5 IPCS INCHEM:Glycerol
6 U. S. FDA Label -Glycerol
7 DrugBank(Pharmacology-Metabolism)Glycerol

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