Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR1007)
Drug Name
Medazepam
Synonyms
Aensius; Ansilan; Azepamide; Benaon; Enobrin; Lerisum; Medaurin; Medazepam [INN:BAN:JAN]; Medazepamum [INN-Latin]; Narsis; Navizil; Nivelton; Nobraksin; Nobral; Nobrium; Nobrium HCl; P0J3387W3S; RB 252; Resmit; Rudotel; Stratium; YLCXGBZIZBEVPZ-UHFFFAOYSA-N; medazepam; 1H-1,4-BENZODIAZEPINE, 7-CHLORO-2,3-DIHYDRO-1-METHYL-5-PHENYL-; 7-Chloro-2,3-dihydro-1-methyl-5-phenyl-1H-1,4-benzodiazepine; BRN 0407983; CHEMBL28333; DEA No. 2836; EINECS 220-783-4; NCGC00164523-01; UNII-P0J3387W3S
Indication Discovery agent Investigative [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 270.75 Topological Polar Surface Area 15.6
Heavy Atom Count 19 Rotatable Bond Count 1
Hydrogen Bond Donor Count 0 Hydrogen Bond Acceptor Count 2
Cross-matching ID
PubChem CID
4041
ChEBI ID
CHEBI:31807
CAS Number
2898-12-6
Formula
C16H15ClN2
Canonical SMILES
CN1CCN=C(C2=C1C=CC(=C2)Cl)C3=CC=CC=C3
InChI
1S/C16H15ClN2/c1-19-10-9-18-16(12-5-3-2-4-6-12)14-11-13(17)7-8-15(14)19/h2-8,11H,9-10H2,1H3
InChIKey
YLCXGBZIZBEVPZ-UHFFFAOYSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Diazepam DM003056
3016
Unclear 1 [3] , [4]
Medazepam metabolite DM005482
15539
Oxidation - N-demethylation 1 [3] , [5]
Desmethyldiazepam DM000834
2997
Oxidation - N-demethylation 2 [3] , [4]
Medazepam metabolite DM003085
5391
Unclear 2 [3] , [4]
Medazepam metabolite DM005483
27855
Unclear 2 [3] , [5]
ACB DM005485
12870
Unclear 3 [3] , [5]
Desmethyldiazepam DM000834
2997
Unclear 3 [3] , [5]
Oxazepam DM003073
4616
Unclear 3 [3] , [4]
ACHB DM005486
6427994
Unclear 4 [3] , [5]
Oxazepam DM003073
4616
Unclear 4 [3] , [5]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR005838 Medazepam Medazepam metabolite Oxidation - N-demethylation Unclear [3], [5]
MR005844 Medazepam Diazepam Unclear Unclear [3], [4]
MR005845 Diazepam Medazepam metabolite Unclear Unclear [3], [4]
MR005847 Diazepam Medazepam metabolite Oxidation - N-demethylation Unclear [3], [4]
MR005839 Medazepam metabolite Medazepam metabolite Unclear Unclear [3], [5]
MR005840 Medazepam metabolite Medazepam metabolite Unclear Unclear [3], [5]
MR005842 Medazepam metabolite ACB Unclear Unclear [3], [5]
MR005846 Medazepam metabolite Oxazepam Unclear Unclear [3], [4]
MR005843 ACB ACHB Unclear Unclear [3], [5]
MR005841 Medazepam metabolite Oxazepam Unclear Unclear [3], [5]
⏷ Show the Full List of 10 MR(s)
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Cytochrome P450 3A4 (CYP3A4) DME0001 Homo sapiens
CP3A4_HUMAN
1.14.14.55
[2]
Mephenytoin 4-hydroxylase (CYP2C19) DME0021 Homo sapiens
CP2CJ_HUMAN
1.14.14.1
[2]
References
1 Pharmaceutical Manufacturing Encyclopedia (Vols 1&2, 2nd Ed)
2 Midazolam and other benzodiazepines. Handb Exp Pharmacol. 2008;(182):335-60.
3 Metabolism of 14C-medazepam hydrochloride in dog, rat and man
4 Plasma concentrations of medazepam and its metabolites after oral administration
5 Further studies on medazepam metabolism in the rat

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