Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR2697)
Drug Name
Oxytetracycline
Synonyms
Oksisyklin; Oxitetraciclina; Oxitetracyclin; Oxitetracyclinum; Oxymycin; Oxypam; Oxyterracin; Oxyterracine; Oxyterracyne; Oxytetracyclin; Oxytetracycline (anhydrous); Oxytetracycline amphoteric; Oxytetracyclinum; Proteroxyna; Riomitsin; Adamycin; Antibiotic TM 25; Berkmycen; Biostat; Dabicycline; Fanterrin; Geomycin; Geotilin; Imperacin; Lenocycline; Liquamycin LA 200; Macocyn; Ryomycin; Solkaciclina; Tarocyn; Tarosin; Teravit; Terrafungine; Terramitsin; Terramycin; Tetran; Ursocyclin; Ursocycline; oxytetracycline; 5-Hydroxytetracycline; 79-57-2
Indication Urethritis/urethral syndrome [ICD11: GC02] Approved [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 460.4 Topological Polar Surface Area 202
Heavy Atom Count 33 Rotatable Bond Count 2
Hydrogen Bond Donor Count 7 Hydrogen Bond Acceptor Count 10
Cross-matching ID
PubChem CID
54675779
ChEBI ID
CHEBI:27701
CAS Number
79-57-2
Formula
C22H24N2O9
Canonical SMILES
CC1(C2C(C3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O)O
InChI
1S/C22H24N2O9/c1-21(32)7-5-4-6-8(25)9(7)15(26)10-12(21)17(28)13-14(24(2)3)16(27)11(20(23)31)19(30)22(13,33)18(10)29/h4-6,12-14,17,25-26,28,30,32-33H,1-3H3,(H2,23,31)/t12-,13-,14+,17+,21-,22+/m1/s1
InChIKey
OWFJMIVZYSDULZ-PXOLEDIWSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Oxytetracycline metabolites DM001142 N. A. Oxidation - Degradation 1 [2]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR001906 Oxytetracycline Oxytetracycline metabolites Oxidation - Degradation Unclear [2]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Unclear metabolic mechanism (DME-unclear) DME1426 Eubacterium cellulosolvens Not Available Not Available [2]
References
1 Oxytetracycline was approved by FDA. The 2020 official website of the U.S. Food and Drug Administration.
2 The changes of bacterial communities and antibiotic resistance genes in microbial fuel cells during long-term oxytetracycline processing. Water Res. 2018 Oct 1;142:105-114.

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