Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR1933)
Drug Name
Sorbitol
Synonyms
Sionit; Sionit K; Sionite; Sionon; Siosan; Sorbex M; Sorbex R; Sorbex Rp; Sorbex S; Sorbex X; Sorbicolan; Sorbilande; Sorbite; Sorbitol F; Sorbitol FP; Sorbitol syrup C; Sorbol; Sorbostyl; Sorvilande; glucitol; sorbitol; Cholaxine; D-(-)-Sorbitol; D-Glucitol; Diakarmon; Esasorb; Foodol D 70; Glucarine; Hexahydric alcohol; Karion; Karion (carbohydrate); Karion instant; L-Gulitol; Multitol; Neosorb; Neosorb 20/60DC; Neosorb 70/02; Neosorb 70/70; Neosorb P 20/60; Neosorb P 60; Nivitin; (-)-Sorbitol; 50-70-4; D-Sorbite; D-Sorbitol; D-Sorbol; d-Sorbit
Indication Asthma [ICD11: CA23] Approved [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 182.17 Topological Polar Surface Area 121
Heavy Atom Count 12 Rotatable Bond Count 5
Hydrogen Bond Donor Count 6 Hydrogen Bond Acceptor Count 6
Cross-matching ID
PubChem CID
5780
ChEBI ID
CHEBI:17924
CAS Number
50-70-4
TTD Drug ID
D09MXS
Formula
C6H14O6
Canonical SMILES
C(C(C(C(C(CO)O)O)O)O)O
InChI
1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
InChIKey
FBPFZTCFMRRESA-JGWLITMVSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Fructose DM005524
2723872
Unclear 1 [2]
Glucose DM003485
5793
Unclear 2 [2]
CO2 DM000908
280
Unclear 3 [4]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR006836 Sorbitol Fructose Unclear SORD [2]
MR006837 Fructose Glucose Unclear SORD [2]
MR006838 Glucose Carbon dioxide Unclear Unclear [4]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Sorbitol dehydrogenase (SORD) DME0578 Homo sapiens
DHSO_HUMAN
1.1.1.14
[2]
Unclear metabolic mechanism (DME-unclear) DME1267 Anaerobutyricum hallii Not Available Not Available [3]
References
1 Sorbitol was approved by FDA. The 2020 official website of the U.S. Food and Drug Administration.
2 Plasma concentration of iditol dehydrogenase (sorbitol dehydrogenase) in ponies treated with aflatoxin B1. Am J Vet Res. 1980 Jun;41(6):925-7.
3 Reclassification of Eubacterium hallii as Anaerobutyricum hallii gen. nov., comb. nov., and description of Anaerobutyricum soehngenii sp. nov., a butyrate and propionate-producing bacterium from infant faeces. Int J Syst Evol Microbiol. 2018 Dec;68(12):3741-3746.
4 An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc., 2006., p. 1498

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.