Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1267)
DME Name Unclear metabolic mechanism (DME-unclear), Anaerobutyricum hallii
Gene Name DME-unclear
Lineage    Species: Anaerobutyricum hallii     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Lachnospiraceae
Genus: Anaerobutyricum
Species: Anaerobutyricum hallii
Subspecies: Anaerobutyricum hallii DSM 17630
Subspecies: Anaerobutyricum hallii DSM 3353
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:        16 Drugs
Mycophenolate mofetil
 Drug Info Approved Crohn disease ICD11: DD70 [1]
Terbinafine hydrochloride
 Drug Info Approved Pityriasis versicolor ICD11: 1F2D [1]
Fluoxetine hydrochloride
 Drug Info Approved Depression ICD11: 6A71 [1]
Eszopiclone
 Drug Info Approved Insomnia ICD11: 7A00 [1]
Omeprazole
 Drug Info Approved Gastro-oesophageal reflux disease ICD11: DA22 [1]
Sulfasalazine
 Drug Info Approved Rheumatoid arthritis ICD11: FA20 [1]
Pantoprazole sodium
 Drug Info Approved Gastro-oesophageal reflux disease ICD11: DA22 [1]
Bromocriptine mesylate
 Drug Info Approved Parkinsonism ICD11: 8A00 [1]
Entacapone
 Drug Info Approved Parkinsonism ICD11: 8A00 [1]
Mannitol
 Drug Info Approved Cerebral oedema ICD11: 8D60 [2]
Melphalan
 Drug Info Approved Multiple myeloma ICD11: 2A83 [1]
Paliperidone
 Drug Info Approved Bipolar disorder ICD11: 6A60 [1]
Tinidazole
 Drug Info Approved Protozoan infection ICD11: 1F5Z [1]
Olmesartan medoxomil
 Drug Info Approved Essential hypertension ICD11: BA00 [1]
Risperidone
 Drug Info Approved Schizophrenia ICD11: 6A20 [1]
Sorbitol
 Drug Info Approved Asthma ICD11: CA23 [2]
      Drugs in Phase 4 Clinical Trial Click to Show/Hide the Full List of Drugs:          5 Drugs
Artemisinin
 Drug Info Phase 4 Malaria ICD11: 1F40 [1]
Phenazopyridine
 Drug Info Phase 4 Infectious cystitis ICD11: GC00 [1]
Trimebutine
 Drug Info Phase 4 Irritable bowel syndrome ICD11: DD91 [1]
L-phenylalanine
 Drug Info Phase 4 Phenylketonuria ICD11: 5C50 [3]
Bisacodyl
 Drug Info Phase 4 Irritable bowel syndrome ICD11: DD91 [1]
      Drugs in Phase 2 Clinical Trial Click to Show/Hide the Full List of Drugs:          3 Drugs
CERC-801
 Drug Info Phase 2 Glycosylation disorder ICD11: 5C54 [2]
TU-199
 Drug Info Phase 2 Gastro-oesophageal reflux disease ICD11: DA22 [1]
R-5495
 Drug Info Phase 2 Congestive heart failure ICD11: BD10 [2]
      Drugs in Phase 1 Clinical Trial Click to Show/Hide the Full List of Drugs:          4 Drugs
M-7403
 Drug Info Phase 1/2 Prostate cancer ICD11: 2C82 [2]
TRP-01
 Drug Info Phase 1 Depression ICD11: 6A71 [3]
Lactose
 Drug Info Phase 1 Lactose intolerance ICD11: 5C61 [2]
BRN-0498823
 Drug Info Phase 1 Essential hypertension ICD11: BA00 [1]
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          6 Drugs
L-tyrosine
 Drug Info Investigative Phenylketonuria ICD11: 5C50 [3]
D-glucose
 Drug Info Investigative Discovery agent ICD: N.A. [2]
Fructose
 Drug Info Investigative Discovery agent ICD: N.A. [2]
Mannose
 Drug Info Investigative Discovery agent ICD: N.A. [2]
Diacetamate
 Drug Info Investigative Discovery agent ICD: N.A. [1]
Sucrose
 Drug Info Investigative Prematurity retinopathy ICD11: 9B71 [2]
References
1 Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467.
2 Reclassification of Eubacterium hallii as Anaerobutyricum hallii gen. nov., comb. nov., and description of Anaerobutyricum soehngenii sp. nov., a butyrate and propionate-producing bacterium from infant faeces. Int J Syst Evol Microbiol. 2018 Dec;68(12):3741-3746.
3 Major phenylpropanoid-derived metabolites in the human gut can arise from microbial fermentation of protein. Mol Nutr Food Res. 2013 Mar;57(3):523-35.

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