Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR2227)
Drug Name
R-5495
Synonyms
D-Ribopyranose; D-Ribopyranoside; D-Ribose; D-Ribose, 99.0%+; R-5495; Ribopyranose; Ribopyranoside; Ribose; SCHEMBL339948; SRBFZHDQGSBBOR-SOOFDHNKSA-N; (3R,4R,5R)-Tetrahydro-2H-pyran-2,3,4,5-tetraol; (3R,4R,5R)-tetrahydro-2H-pyran-2,3,4,5-tetrol; 10257-32-6; C21057; CHEBI:47006; CTK0H1736; D-Rib; DTXSID70450356; EC 700-481-3; Rib; D-ribose
Indication Congestive heart failure [ICD11: BD10] Phase 2 [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 150.13 Topological Polar Surface Area 90.2
Heavy Atom Count 10 Rotatable Bond Count 0
Hydrogen Bond Donor Count 4 Hydrogen Bond Acceptor Count 5
Cross-matching ID
PubChem CID
10975657
ChEBI ID
CHEBI:47006
CAS Number
10257-32-6
Formula
C5H10O5
Canonical SMILES
C1C(C(C(C(O1)O)O)O)O
InChI
1S/C5H10O5/c6-2-1-10-5(9)4(8)3(2)7/h2-9H,1H2/t2-,3-,4-,5?/m1/s1
InChIKey
SRBFZHDQGSBBOR-SOOFDHNKSA-N
The Predicted Metabolic Roadmap of This Drug
The Full List of Predicted Drug Metabolites (PDM) of This Drug
PDM Name PDM ID PubChem ID Reaction PDM Level Biosystem
R-5495 M1 PDM007476 N. A. Conjugation - Alkyl-OH-glucuronidation 1 Human
R-5495 M2 PDM007477 N. A. Conjugation - Alkyl-OH-glucuronidation 1 Human
R-5495 M3 PDM007478
131752919
Conjugation - Alkyl-OH-glucuronidation 1 Human
R-5495 M4 PDM007479 N. A. Conjugation - Sulfation of secondary alcohol 1 Human
R-5495 M5 PDM007480 N. A. Conjugation - Sulfation of secondary alcohol 1 Human
R-5495 M6 PDM007481 N. A. Conjugation - Sulfation of secondary alcohol 1 Human
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Unclear metabolic mechanism (DME-unclear) DME1267 Anaerobutyricum hallii Not Available Not Available [2]
References
1 ClinicalTrials.gov (NCT01858480) Study To Evaluate D-Ribose For The Treatment of Congestive Heart Failure
2 Reclassification of Eubacterium hallii as Anaerobutyricum hallii gen. nov., comb. nov., and description of Anaerobutyricum soehngenii sp. nov., a butyrate and propionate-producing bacterium from infant faeces. Int J Syst Evol Microbiol. 2018 Dec;68(12):3741-3746.

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