General Information of Drug (ID: DR2966)
Drug Name	Rolafagrel
Synonyms	FCE-22178
Indication	Nephritis [ICD11: GB40]				Discontinued in Phase 2	[1]
Structure
	3D MOL			2D MOL
Pharmaceutical Properties	Molecular Weight		240.26	Topological Polar Surface Area		55.1
	Heavy Atom Count		18	Rotatable Bond Count		2
	Hydrogen Bond Donor Count		1	Hydrogen Bond Acceptor Count		3
Cross-matching ID	PubChem CID 56009 CAS Number 89781-55-5 TTD Drug ID D0V7GC Formula C14H12N2O2 Canonical SMILES C1CC(=CC2=C1C=CC(=C2)C(=O)O)N3C=CN=C3 InChI InChI=1S/C14H12N2O2/c17-14(18)11-2-1-10-3-4-13(8-12(10)7-11)16-6-5-15-9-16/h1-2,5-9H,3-4H2,(H,17,18) InChIKey DQEDSIVMYUUZCK-UHFFFAOYSA-N

The Metabolic Roadmap of This Drug

The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF Rolafagrel Metabolite A DM017791 N. A. Unclear - Unclear 1 [2]

The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF MR009323 Rolafagrel Rolafagrel Metabolite A Unclear - Unclear GUSB [2]

References
1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001438)
2	In vivo glucuronidation in rat and humans of 5,6-dihydro-7-(1H-imidazol-1-yl)-naphthalene-2-carboxylic acid, a selective inhibitor of thromboxane synthase

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