Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000020)
Formula Reactant ACP-5134 Product Acalabrutinib M24 metabolite
Reactant Info Product Info
Metabolic Type Reduction - Reduction
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000025 Acalabrutinib ACP-5134 Other reaction - Hydration Acalabrutinib [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000021 ACP-5134 Acalabrutinib M45 metabolite Reduction - Reduction Acalabrutinib [1]
References
1 Bioavailability, Biotransformation, and Excretion of the Covalent Bruton Tyrosine Kinase Inhibitor Acalabrutinib in Rats, Dogs, and Humans Drug Metab Dispos. 2019 Feb;47(2):145-154. doi: 10.1124/dmd.118.084459.

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