Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000021)
Formula	Reduction
	Reactant	ACP-5134	Product	Acalabrutinib M45 metabolite
	Reactant	Reactant Info	Product	Product Info
Metabolic Type	Reduction - Reduction

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Produce The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR000025	Acalabrutinib	ACP-5134	Other reaction - Hydration	Acalabrutinib	[1]

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR000020	ACP-5134	Acalabrutinib M24 metabolite	Reduction - Reduction	Acalabrutinib	[1]

References
1	Bioavailability, Biotransformation, and Excretion of the Covalent Bruton Tyrosine Kinase Inhibitor Acalabrutinib in Rats, Dogs, and Humans Drug Metab Dispos. 2019 Feb;47(2):145-154. doi: 10.1124/dmd.118.084459.

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