Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000043)
Formula Reactant Indomethacin Product Indometacin glycine
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001200 Indomethacin 5-hydroxyindomethacin Oxidation - O-Demethylation Indomethacin [1]
MR001201 Indomethacin Deacyl indomethacin Unclear Indomethacin [1]
MR001202 Indomethacin Indomethacin acyl glucuronide Conjugation - O-Glucuronidation Indomethacin [2], [3]
References
1 Comparative in vitro metabolism of phospho-tyrosol-indomethacin by mice, rats and humans Biochem Pharmacol. 2013 Apr 15;85(8):1195-202. doi: 10.1016/j.bcp.2013.01.031.
2 Contribution of UDP-glucuronosyltransferases 1A9 and 2B7 to the glucuronidation of indomethacin in the human liver. Eur J Clin Pharmacol. 2007 Mar;63(3):289-96.
3 Herb-drug interaction in the protective effect of Alpinia officinarum against gastric injury induced by indomethacin based on pharmacokinetic, tissue distribution and excretion studies in rats. J Pharm Anal. 2021 Apr;11(2):200-209. doi: 10.1016/j.jpha.2020.05.009.

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