Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001201)
Formula
SVG example
Reactant Indomethacin Product Deacyl indomethacin
Reactant Info Product Info
Metabolic Enzyme Carboxylesterase 1 (CES1) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001200 Indomethacin 5-hydroxyindomethacin Oxidation - O-Demethylation Indomethacin [1]
MR001202 Indomethacin Indomethacin acyl glucuronide Conjugation - O-Glucuronidation Indomethacin [2], [3]
MR000043 Indomethacin Indometacin glycine Unclear Acemetacin [4]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000039 Acemetacin Deacyl indomethacin Other reaction - N-Dehydroxylation; Hydrolysis Acemetacin [5]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000034 Deacyl indomethacin Deacyl indomethacin glucuronide Unclear Acemetacin [5]
MR001199 Deacyl indomethacin Deacyl indomethacin glucuronide Conjugation - Glucuronidation Indomethacin [1]
MR001198 Deacyl indomethacin O-Desmethyl-N-deschlorobenzoyl indomethacin Oxidation - O-Demethylation Indomethacin [1]
References
1 Comparative in vitro metabolism of phospho-tyrosol-indomethacin by mice, rats and humans Biochem Pharmacol. 2013 Apr 15;85(8):1195-202. doi: 10.1016/j.bcp.2013.01.031.
2 Contribution of UDP-glucuronosyltransferases 1A9 and 2B7 to the glucuronidation of indomethacin in the human liver. Eur J Clin Pharmacol. 2007 Mar;63(3):289-96.
3 Herb-drug interaction in the protective effect of Alpinia officinarum against gastric injury induced by indomethacin based on pharmacokinetic, tissue distribution and excretion studies in rats. J Pharm Anal. 2021 Apr;11(2):200-209. doi: 10.1016/j.jpha.2020.05.009.
4 [Comparative metabolic studies on [14C]-labelled acemetacin and indometacin in rats (author's transl)] Arzneimittelforschung. 1980;30(8A):1384-91.
5 DrugBank(Pharmacology-Metabolism)Acemetacin

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