Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000202)
Formula
GLUL ...
SVG example
Condensation
Reactant Ammonia Product Glutamine
Reactant Info Product Info
Metabolic Enzyme Glutamine synthetase (GLUL) DME Info
L-glutamine amidohydrolase (GLS) DME Info
Metabolic Type Conjugation - Condensation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000204 Ammonia L-arginine Unclear Ammonia [1]
MR000201 Ammonia L-citrulline Unclear Ammonia [1]
MR000200 Ammonia L-glutamate Unclear Ammonia [2]
MR000203 Ammonia Urea Unclear Ammonia [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003638 Glutamic acid Glutamine Unclear Glutamic acid [4]
MR004453 Glutamate Glutamine Unclear Oxoglutarate [5]
MR000199 L-glutamate Glutamine Unclear Ammonia [6]
MR004930 2-(o-carboxybenzamido)glutaramic acid L-Glutamine Conjugation - Amide Hydrolyation Thalidomide [7]
MR014138 2-(o-carboxybenzamido)glutaric acid L-Glutamine Conjugation - Amide Hydrolyation Thalidomide [7]
MR012744 L-Glutamate L-Glutamine Unclear - Unclear Arginine [8]
MR014139 L-Glutamine L-Glutamine Conjugation - Amide Hydrolyation Thalidomide [7]
⏷ Show the Full List of MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR014139 L-Glutamine L-Glutamine Conjugation - Amide Hydrolyation Thalidomide [7]
References
1 Ammonia metabolism and hyperammonemic disorders Adv Clin Chem. 2014;67:73-150. doi: 10.1016/bs.acc.2014.09.002.
2 Model-guided identification of a therapeutic strategy to reduce hyperammonemia in liver diseases J Hepatol. 2016 Apr;64(4):860-71. doi: 10.1016/j.jhep.2015.11.018.
3 Ammonia Transporters and Their Role in Acid-Base Balance Physiol Rev. 2017 Apr;97(2):465-494. doi: 10.1152/physrev.00011.2016.
4 Glutamate metabolism and recycling at the excitatory synapse in health and neurodegeneration
5 The Emergence of 2-Oxoglutarate as a Master Regulator Metabolite
6 Metabolism of glutamate and ammonia in astrocyte: an immunocytochemical study Brain Res. 1988 Aug 2;457(1):160-4. doi: 10.1016/0006-8993(88)90069-8.
7 Thalidomide metabolism and hydrolysis: mechanisms and implications
8 Arginine Metabolism Revisited

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.