Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000203)
Formula
SVG example
Reactant Ammonia Product Urea
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000202 Ammonia Glutamine Conjugation - Condensation Ammonia [1]
MR000204 Ammonia L-arginine Unclear Ammonia [2]
MR000201 Ammonia L-citrulline Unclear Ammonia [2]
MR000200 Ammonia L-glutamate Unclear Ammonia [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003078 Agmatine Urea Unclear Agmatine [3]
MR004282 [1-(2-aminoimidazol-1-yl)-3-methoxypropan-2-ol] (AIM) Urea Hydrolysis - Hydrolyzation Misonidazole [4]
MR003075 Gamma-guanidinobutyrate Urea Unclear Agmatine [3], [5]
MR004034 Allantoic acid Urea Unclear Xanthine [6]
MR005276 FUPA Urea Hydrolysis - Hydrolysis Tegafur-uracil [7]
References
1 Model-guided identification of a therapeutic strategy to reduce hyperammonemia in liver diseases J Hepatol. 2016 Apr;64(4):860-71. doi: 10.1016/j.jhep.2015.11.018.
2 Ammonia metabolism and hyperammonemic disorders Adv Clin Chem. 2014;67:73-150. doi: 10.1016/bs.acc.2014.09.002.
3 Metabolism and function in animal tissues of agmatine, a biogenic amine formed from arginine Amino Acids. 2004 Feb;26(1):3-8. doi: 10.1007/s00726-003-0030-z.
4 Comparative misonidazole metabolism in anaerobic bacteria and hypoxic Chinese hamster lung fibroblast (V-79-473) cells
5 A guanidine-degrading enzyme controls genomic stability of ethylene-producing cyanobacteria. Nat Commun. 2021 Aug 26;12(1):5150. doi: 10.1038/s41467-021-25369-x.
6 Xanthine metabolism in Bacillus subtilis: characterization of the xpt-pbuX operon and evidence for purine- and nitrogen-controlled expression of genes involved in xanthine salvage and catabolism
7 DrugBank(Pharmacology-Metabolism):Tegafur-uracil

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