Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000239)
Formula
SVG example
N-Dealkylation
Reactant Anastrozole Product Triazole
Reactant Info Product Info
Metabolic Type Oxidation - N-Dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000240 Anastrozole 3,5-Bis-(2-methylpropiononitrile)-benzoic acid Oxidation - N-Dealkylation Anastrozole [1]
MR000238 Anastrozole Anastrozole glucuronide metabolite Unclear Anastrozole [2], [3]
MR000237 Anastrozole Hydroxyanastrozole Oxidation - Hydroxylation Anastrozole [1]
References
1 In vitro and in vivo oxidative metabolism and glucuronidation of anastrozole. Br J Clin Pharmacol. 2010 Dec;70(6):854-69.
2 Oxidative metabolism of amprenavir in the human liver. Effect of the CYP3A maturation. Drug Metab Dispos. 2003 Mar;31(3):275-81.
3 Anastrozole and related glucuronic acid conjugate are electrophilic species. Xenobiotica. 2022 Apr;52(4):380-388. doi: 10.1080/00498254.2022.2086503.

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