Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000240)
Formula
SVG example
N-Dealkylation
Reactant Anastrozole Product 3,5-Bis-(2-methylpropiononitrile)-benzoic acid
Reactant Info Product Info
Metabolic Type Oxidation - N-Dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000238 Anastrozole Anastrozole glucuronide metabolite Unclear Anastrozole [1], [2]
MR000237 Anastrozole Hydroxyanastrozole Oxidation - Hydroxylation Anastrozole [3]
MR000239 Anastrozole Triazole Oxidation - N-Dealkylation Anastrozole [3]
References
1 Oxidative metabolism of amprenavir in the human liver. Effect of the CYP3A maturation. Drug Metab Dispos. 2003 Mar;31(3):275-81.
2 Anastrozole and related glucuronic acid conjugate are electrophilic species. Xenobiotica. 2022 Apr;52(4):380-388. doi: 10.1080/00498254.2022.2086503.
3 In vitro and in vivo oxidative metabolism and glucuronidation of anastrozole. Br J Clin Pharmacol. 2010 Dec;70(6):854-69.

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