Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000250)
Formula Reactant Apomorphine Product Apocodeine sulfate
Reactant Info Product Info
Metabolic Enzyme Sulfotransferase 1A1 (SULT1A1) DME Info
Metabolic Type Conjugation - Conjugation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000251 Apomorphine Apocodeine Conjugation - O-Methylation Apomorphine [1]
MR000254 Apomorphine Apomorphine 10-glucuronide Conjugation - O-Glucuronidation Apomorphine [2]
MR000255 Apomorphine Apomorphine 11-glucuronide Conjugation - O-Glucuronidation Apomorphine [2]
MR000252 Apomorphine Isoapocodeine Conjugation - O-Methylation Apomorphine [1]
MR000256 Apomorphine Norapomorphine Oxidation - N-Demethylation Apomorphine [3]
MR000253 Apomorphine O-quinone Oxidation - Oxidation Apomorphine [4]
References
1 Pharmacokinetics, enantiomer interconversion, and metabolism of R-apomorphine in patients with idiopathic Parkinson's disease Clin Neuropharmacol. 1998 May-Jun;21(3):159-68.
2 Glucuronidation of apomorphine Life Sci. 2000 Aug 25;67(14):1735-45. doi: 10.1016/s0024-3205(00)00764-5.
3 The pharmacology and clinical pharmacokinetics of apomorphine SL BJU Int. 2001 Oct;88 Suppl 3:18-21. doi: 10.1046/j.1464-4096.2001.00124.x.
4 DrugBank(Pharmacology-Metabolism)Apomorphine

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