Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000251)
Formula
SVG example
O-Methylation
Reactant Apomorphine Product Apocodeine
Reactant Info Product Info
Metabolic Enzyme Catechol O-methyltransferase (COMT) DME Info
Metabolic Type Conjugation - O-Methylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000250 Apomorphine Apocodeine sulfate Conjugation - Conjugation Apomorphine [1], [2]
MR000254 Apomorphine Apomorphine 10-glucuronide Conjugation - O-Glucuronidation Apomorphine [3]
MR000255 Apomorphine Apomorphine 11-glucuronide Conjugation - O-Glucuronidation Apomorphine [3]
MR000252 Apomorphine Isoapocodeine Conjugation - O-Methylation Apomorphine [2]
MR000256 Apomorphine Norapomorphine Oxidation - N-Demethylation Apomorphine [4]
MR000253 Apomorphine O-quinone Oxidation - Oxidation Apomorphine [5]
References
1 Sulfation of apomorphine by human sulfotransferases: evidence of a major role for the polymorphic phenol sulfotransferase, SULT1A1. Xenobiotica. 2003 Nov;33(11):1139-48.
2 Pharmacokinetics, enantiomer interconversion, and metabolism of R-apomorphine in patients with idiopathic Parkinson's disease Clin Neuropharmacol. 1998 May-Jun;21(3):159-68.
3 Glucuronidation of apomorphine Life Sci. 2000 Aug 25;67(14):1735-45. doi: 10.1016/s0024-3205(00)00764-5.
4 The pharmacology and clinical pharmacokinetics of apomorphine SL BJU Int. 2001 Oct;88 Suppl 3:18-21. doi: 10.1046/j.1464-4096.2001.00124.x.
5 DrugBank(Pharmacology-Metabolism)Apomorphine

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