Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000272)
Formula
SVG example
Glucuronidation
Reactant Apremilast metabolite M4 Product Apremilast metabolite M14
Reactant Info Product Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000276 Apremilast O-desmethyl Apremilast Oxidation - O-Demethylation Apremilast [1]
MR000268 Apremilast metabolite M7 Apremilast metabolite M4 Oxidation - O-Demethylation Apremilast [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000259 O-desmethyl Apremilast Apremilast metabolite M19 Oxidation - O-Demethylation Apremilast [1]
MR000258 O-desmethyl Apremilast Apremilast metabolite M9 Hydrolysis - Hydrolysis Apremilast [1]
MR000257 O-desmethyl Apremilast O-desmethyl apremilast glucuronide Conjugation - Glucuronidation Apremilast [1]
MR000271 Apremilast metabolite M4 Apremilast metabolite M20 Oxidation - O-Deethylation Apremilast [1]
MR000270 Apremilast metabolite M4 Apremilast metabolite M8 Unclear Apremilast [1]
References
1 Disposition, metabolism and mass balance of [(14)C]apremilast following oral administration. Xenobiotica. 2011 Dec;41(12):1063-75.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.