Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000268)
Formula Reactant Apremilast metabolite M7 Product Apremilast metabolite M4
Reactant Info Product Info
Metabolic Type Oxidation - O-Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000279 Apremilast Apremilast metabolite M7 Oxidation - N-Deacetylation Apremilast [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000267 Apremilast metabolite M7 Apremilast metabolite M11 Oxidation - Hydroxylation Apremilast [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000276 Apremilast O-desmethyl Apremilast Oxidation - O-Demethylation Apremilast [1]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000259 O-desmethyl Apremilast Apremilast metabolite M19 Oxidation - O-Demethylation Apremilast [1]
MR000258 O-desmethyl Apremilast Apremilast metabolite M9 Hydrolysis - Hydrolysis Apremilast [1]
MR000257 O-desmethyl Apremilast O-desmethyl apremilast glucuronide Conjugation - Glucuronidation Apremilast [1]
MR000272 Apremilast metabolite M4 Apremilast metabolite M14 Conjugation - Glucuronidation Apremilast [1]
MR000271 Apremilast metabolite M4 Apremilast metabolite M20 Oxidation - O-Deethylation Apremilast [1]
MR000270 Apremilast metabolite M4 Apremilast metabolite M8 Unclear Apremilast [1]
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References
1 Disposition, metabolism and mass balance of [(14)C]apremilast following oral administration. Xenobiotica. 2011 Dec;41(12):1063-75.

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