Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000298)
Formula
CYP2B6 ...
SVG example
Oxidation
Reactant Artemether Product Dihydroartemisinin
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2B6 (CYP2B6) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000299 Artemether 9,10-dihydrodeoxy-artemsinin Unclear Artemether [1]
MR000300 Artemether Alpha-dihydroartemisinin Unclear Artemether [1]
MR000301 Artemether Deoxyartemsinin Unclear Artemether [1]
MR000302 Artemether Deoxydihydro-artemisinin Unclear Artemether [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005413 Artesunate Dihydroartemisinin Unclear Artesunate [2], [3]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005414 Dihydroartemisinin Dihydroartemisinin Glucuronide Unclear Artesunate [4], [5]
References
1 DrugBank(Pharmacology-Metabolism)Artemether
2 Predicting the Disposition of the Antimalarial Drug Artesunate and Its Active Metabolite Dihydroartemisinin Using Physiologically Based Pharmacokinetic Modeling
3 Review of the clinical pharmacokinetics of artesunate and its active metabolite dihydroartemisinin following intravenous, intramuscular, oral or rectal administration
4 Glucuronidation of dihydroartemisinin in vivo and by human liver microsomes and expressed UDP-glucuronosyltransferases
5 LC-MS/MS method for the simultaneous quantification of artesunate and its metabolites dihydroartemisinin and dihydroartemisinin glucuronide in human plasma

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