Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005413)
Formula
SVG example
Reactant Artesunate Product Dihydroartemisinin
Reactant Info Product Info
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000298 Artemether Dihydroartemisinin Oxidation - Oxidation Artemether [1]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005414 Dihydroartemisinin Dihydroartemisinin Glucuronide Unclear Artesunate [2], [3]
References
1 Use of a physiologically-based pharmacokinetic model to simulate artemether dose adjustment for overcoming the drug-drug interaction with efavirenz In Silico Pharmacol. 2013 Mar 1;1:4. doi: 10.1186/2193-9616-1-4.
2 Glucuronidation of dihydroartemisinin in vivo and by human liver microsomes and expressed UDP-glucuronosyltransferases
3 LC-MS/MS method for the simultaneous quantification of artesunate and its metabolites dihydroartemisinin and dihydroartemisinin glucuronide in human plasma

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.