Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000321)
Formula	Reactant	N-desmethylasenapine	Product	10,11-dihydroxy-N-desmethyl asenapine
Formula	Reactant	Reactant Info	Product	Product Info

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Produce The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR000326	Asenapine maleate	N-desmethylasenapine	Unclear	Asenapine maleate	[1]

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR000323	N-desmethylasenapine	11-hydroxy-N-formyl-N-desmethylasenapine	Unclear	Asenapine maleate	[1]
MR000322	N-desmethylasenapine	Asenapine maleate glucuronide metabolite	Conjugation - Glucuronidation	Asenapine maleate	[1]
MR000325	N-desmethylasenapine	Hydroxy-N-formyl-N-desmethylasenapine	Unclear	Asenapine maleate	[1]
MR000324	N-desmethylasenapine	N-desmethylasenapine-N-carbamoylglucuronide	Unclear	Asenapine maleate	[1]

References
1	Asenapine review, part I: chemistry, receptor affinity profile, pharmacokinetics and metabolism. Expert Opin Drug Metab Toxicol. 2014 Jun;10(6):893-903.

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