Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000326)
Formula Reactant Asenapine maleate Product N-desmethylasenapine
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000327 Asenapine maleate 10,11-dihydroxyasenapine Unclear Asenapine maleate [1]
MR000328 Asenapine maleate Asenapine-N-glucuronide Conjugation - N-Glucuronidation Asenapine maleate [1]
MR000329 Asenapine maleate Asenapine-N-oxide Unclear Asenapine maleate [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000321 N-desmethylasenapine 10,11-dihydroxy-N-desmethyl asenapine Unclear Asenapine maleate [1]
MR000323 N-desmethylasenapine 11-hydroxy-N-formyl-N-desmethylasenapine Unclear Asenapine maleate [1]
MR000322 N-desmethylasenapine Asenapine maleate glucuronide metabolite Conjugation - Glucuronidation Asenapine maleate [1]
MR000325 N-desmethylasenapine Hydroxy-N-formyl-N-desmethylasenapine Unclear Asenapine maleate [1]
MR000324 N-desmethylasenapine N-desmethylasenapine-N-carbamoylglucuronide Unclear Asenapine maleate [1]
References
1 Asenapine review, part I: chemistry, receptor affinity profile, pharmacokinetics and metabolism. Expert Opin Drug Metab Toxicol. 2014 Jun;10(6):893-903.

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