Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000328)
Formula
SVG example
N-Glucuronidation
Reactant Asenapine maleate Product Asenapine-N-glucuronide
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A4 (UGT1A4) DME Info
Metabolic Type Conjugation - N-Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000327 Asenapine maleate 10,11-dihydroxyasenapine Unclear Asenapine maleate [1]
MR000329 Asenapine maleate Asenapine-N-oxide Unclear Asenapine maleate [1]
MR000326 Asenapine maleate N-desmethylasenapine Unclear Asenapine maleate [1]
References
1 Asenapine review, part I: chemistry, receptor affinity profile, pharmacokinetics and metabolism. Expert Opin Drug Metab Toxicol. 2014 Jun;10(6):893-903.

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