Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000335)
Formula
SVG example
N-Dealkylation
Reactant Desmethylastemizole Product Tecastemizole
Reactant Info Product Info
Metabolic Type Oxidation - N-Dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006260 Desmethylastemizole 6-Hydroxydesmethylastemizole Oxidation - 6-Hydrolyzationn Desmethylastemizole [1]
MR006262 Desmethylastemizole CO-glucuronide Conjugation - Glucuronidation Desmethylastemizole [1]
MR000334 Desmethylastemizole 6-hydroxydesmethylastemizole Oxidation - 6-Hydroxylation Astemizole [1]
References
1 Involvement of multiple human cytochromes P450 in the liver microsomal metabolism of astemizole and a comparison with terfenadine. Br J Clin Pharmacol. 2001 Feb;51(2):133-42.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.