Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006262)
Formula Reactant Desmethylastemizole Product CO-glucuronide
Reactant Info Product Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006260 Desmethylastemizole 6-Hydroxydesmethylastemizole Oxidation - 6-Hydrolyzationn Desmethylastemizole [1]
MR006261 Desmethylastemizole Norastemizole Oxidation - N-Dealkylation Desmethylastemizole [1]
MR000334 Desmethylastemizole 6-hydroxydesmethylastemizole Oxidation - 6-Hydroxylation Astemizole [1]
MR000335 Desmethylastemizole Tecastemizole Oxidation - N-Dealkylation Astemizole [1]
References
1 Involvement of multiple human cytochromes P450 in the liver microsomal metabolism of astemizole and a comparison with terfenadine. Br J Clin Pharmacol. 2001 Feb;51(2):133-42.

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