Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000409)
Formula
CYP2C9 ...
SVG example
Oxidation; Deboronation
Reactant Bortezomib Product Bortezomib metabolite M2
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C9 (CYP2C9) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Oxidation; Deboronation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000408 Bortezomib Bortezomib metabolite M1 Oxidation - Oxidative Deboronation Bortezomib [1]
MR000411 Bortezomib Bortezomib metabolite M23 Unclear Bortezomib [1]
MR000412 Bortezomib Bortezomib metabolite M24 Unclear Bortezomib [1]
MR000410 Bortezomib Bortezomib metabolite M34 Unclear Bortezomib [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000405 Bortezomib metabolite M2 Bortezomib metabolite M27 Oxidation - Hydoxylation Bortezomib [1]
MR000404 Bortezomib metabolite M2 Bortezomib metabolite M28 Oxidation - Hydoxylation Bortezomib [1]
MR000402 Bortezomib metabolite M2 Bortezomib metabolite M3 Hydrolysis - Hydrolysis Bortezomib [1]
MR000406 Bortezomib metabolite M2 Bortezomib metabolite M6 Oxidation - Hydoxylation Bortezomib [1]
MR000403 Bortezomib metabolite M2 Bortezomib metabolite M8 Oxidation - Hydoxylation Bortezomib [1]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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