Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000413)
Formula
SVG example
Methyl-Hydroxylation
Reactant Bosentan metabolite Ro 47-8634 Product Bosentan metabolite Ro 64-1056
Reactant Info Product Info
Metabolic Type Oxidation - Methyl-Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000416 Bosentan Bosentan metabolite Ro 47-8634 Oxidation - O-Demethylation Bosentan [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000415 Bosentan metabolite Ro 48-5033 Bosentan metabolite Ro 64-1056 Oxidation - O-Demethylation Bosentan [1]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000414 Bosentan metabolite Ro 64-1056 Bosentan metabolite M4 Unclear Bosentan [1]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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