Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000501)
Formula Reactant R-4'-hydroxybupropion Product R,S-erythro-4'-hydroxy-hydrobupropion
Reactant Info Product Info
Metabolic Enzyme Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DME Info
Aflatoxin B1 aldehyde reductase member 3 (AKR7A3) DME Info
Metabolic Type Reduction - Ketoreduction
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000515 Bupropion R-4'-hydroxybupropion Oxidation - Hydroxylation Bupropion [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000504 R-4'-hydroxybupropion R,R-threo-4'-hydroxy-hydrobupropion Reduction - Ketoreduction Bupropion [1]
MR000503 R-4'-hydroxybupropion R-4'-hydroxybupropion glucuronide Conjugation - Glucuronidation Bupropion [1]
MR000502 R-4'-hydroxybupropion R-4'-hydroxybupropion sulfate Conjugation - Sulfation Bupropion [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000509 R,S-erythrohydrobupropion R,S-erythro-4'-hydroxy-hydrobupropion Oxidation - 4'-Hydroxylation Bupropion [1]
MR000499 S-4'-hydroxybupropion R,S-erythro-4'-hydroxy-hydrobupropion Reduction - Ketoreduction Bupropion [1]
References
1 DrugBank(Pharmacology-Metabolism)Bupropion

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