Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000505)
Formula
SVG example
4'-Hydroxylation
Reactant R,R-threohydrobupropion Product R,R-threo-4'-hydroxy-hydrobupropion
Reactant Info Product Info
Metabolic Enzyme Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Metabolic Type Oxidation - 4'-Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000516 Bupropion R,R-threohydrobupropion Reduction - Ketoreduction Bupropion [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000506 R,R-threohydrobupropion R,R-threohydrobupropion glucuronide Conjugation - Glucuronidation Bupropion [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000504 R-4'-hydroxybupropion R,R-threo-4'-hydroxy-hydrobupropion Reduction - Ketoreduction Bupropion [1]
References
1 DrugBank(Pharmacology-Metabolism)Bupropion

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