Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000570)
Formula
CYP2D6 ...
SVG example
4'-Hydroxylation
Reactant Carvedilol Product 4'-hydroxyphenylcarvedilol
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 2E1 (CYP2E1) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Metabolic Type Oxidation - 4'-Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000573 Carvedilol 1-hydroxyphenylcarvedilol Oxidation - 1-Hydroxylation Carvedilol [1]
MR000571 Carvedilol 5'-hydroxyphenylcarvedilol Oxidation - 5'-Hydroxylation Carvedilol [1]
MR000569 Carvedilol 8-hydroxycarbazolylcarvedilol Oxidation - 8-Hydroxylation Carvedilol [1]
MR000574 Carvedilol Carvedilol glucuronide Conjugation - O-Glucuronidation Carvedilol [1]
MR000572 Carvedilol O-Desmethylcarvedilol Oxidation - O-Demethylation Carvedilol [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000565 4'-hydroxyphenylcarvedilol Carvedilol metabolite M29 Conjugation - Glucuronidation Carvedilol [1]
References
1 Metabolism of carvedilol in dogs, rats, and mice Drug Metab Dispos. 1998 Oct;26(10):958-69.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.