Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000573)
Formula
PTGS1 ...
SVG example
1-Hydroxylation
Reactant Carvedilol Product 1-hydroxyphenylcarvedilol
Reactant Info Product Info
Metabolic Enzyme Prostaglandin G/H synthase 1 (COX-1) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 1A1 (CYP1A1) DME Info
Metabolic Type Oxidation - 1-Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000570 Carvedilol 4'-hydroxyphenylcarvedilol Oxidation - 4'-Hydroxylation Carvedilol [1]
MR000571 Carvedilol 5'-hydroxyphenylcarvedilol Oxidation - 5'-Hydroxylation Carvedilol [1]
MR000569 Carvedilol 8-hydroxycarbazolylcarvedilol Oxidation - 8-Hydroxylation Carvedilol [1]
MR000574 Carvedilol Carvedilol glucuronide Conjugation - O-Glucuronidation Carvedilol [1]
MR000572 Carvedilol O-Desmethylcarvedilol Oxidation - O-Demethylation Carvedilol [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000568 1-hydroxyphenylcarvedilol Carvedilol metabolite M15 Conjugation - Glucuronidation Carvedilol [1]
References
1 Metabolism of carvedilol in dogs, rats, and mice Drug Metab Dispos. 1998 Oct;26(10):958-69.

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