Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000803)
Formula
SVG example
Hydroxylation
Reactant Dexmedetomidine hydrochloride Product MPV-1305
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2A6 (CYP2A6) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000804 Dexmedetomidine hydrochloride Dexmedetomidine N-glucuronidation Conjugation - Glucuronidation Dexmedetomidine hydrochloride [1]
MR000802 Dexmedetomidine hydrochloride MPV-1709 Conjugation - N-Methylation Dexmedetomidine hydrochloride [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000800 MPV-1305 Hydroxydexmedetomidine-O-glucuronidation Conjugation - Glucuronidation Dexmedetomidine hydrochloride [2]
MR000801 MPV-1305 MPV-1036 Unclear Dexmedetomidine hydrochloride [2]
References
1 Large inter-individual variability in pharmacokinetics of dexmedetomidine and its two major N-glucuronides in adult intensive care unit patients J Pharm Biomed Anal. 2019 Oct 25;175:112777. doi: 10.1016/j.jpba.2019.07.025.
2 Analytical method development for the simultaneous quantitation of dexmedetomidine and three potential metabolites in plasma J Chromatogr A. 1997 Feb 21;762(1-2):281-91. doi: 10.1016/s0021-9673(96)00965-x.

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