Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000957)
Formula
SVG example
Reactant Estromustine Product Estrone
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000959 Estramustine Estromustine Unclear Estramustine [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004101 Conjugated estrogens Estrone Reduction - Reduction Conjugated estrogens [3]
MR013320 E-3A Estrone Unclear E-3A [4]
MR004241 Estrone sulfate Estrone Unclear Estrone sulfate [5]
MR000967 Estropipate Estrone Unclear Estropipate [6]
MR013309 17Beta-Estradiol-3,17-beta-sulfate Estrone Unclear E-3A [7]
MR003147 4-androstene-3,17-dione(AD) Estrone Unclear Dehydroepiandrosterone [8]
MR002636 Estradiol Estrone Unclear Estradiol acetate [4]
MR002659 Estradiol Estrone Unclear Estradiol cypionate [4]
MR002682 Estradiol Estrone Unclear Estradiol valerate [4]
MR002637 17beta-Estradiol-3,17-beta-sulfate Estrone Unclear Estradiol acetate [7]
MR002660 17beta-Estradiol-3,17-beta-sulfate Estrone Unclear Estradiol cypionate [7]
MR002683 17beta-Estradiol-3,17-beta-sulfate Estrone Unclear Estradiol valerate [7]
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References
1 Simultaneous determination of estramustine phosphate and its four metabolites in human plasma by liquid chromatography-ionspray mass spectrometry Biomed Chromatogr. 2004 Jun;18(5):293-301. doi: 10.1002/bmc.319.
2 Differential uptake of estramustine phosphate metabolites and its correlation with the levels of estramustine binding protein in prostate tumor tissue Clin Cancer Res. 1998 Sep;4(9):2079-84.
3 Conjugated estrogens and bazedoxifene
4 Cytochrome P450-mediated metabolism of estrogens and its regulation in human. Cancer Lett. 2005 Sep 28;227(2):115-24.
5 Estrone Sulfate Transport and Steroid Sulfatase Activity in Colorectal Cancer: Implications for Hormone Replacement Therapy
6 DrugBank(Pharmacology-Metabolism)Estropipate
7 Cytochrome P450 1A2 (CYP1A2) activity and risk factors for breast cancer: a cross-sectional study. Breast Cancer Res. 2004;6(4):R352-65.
8 Resveratrol Inhibits Key Steps of Steroid Metabolism in a Human Estrogen-Receptor Positive Breast Cancer Model: Impact on Cellular Proliferation Front Pharmacol. 2018 Jul 10;9:742. doi: 10.3389/fphar.2018.00742.

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