Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013320)
Formula
SVG example
Reactant E-3A Product Estrone
Reactant Info Product Info
Metabolic Enzyme Estradiol 17-beta-dehydrogenase 2 (HSD17B2) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013329 E-3A 17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide) Unclear E-3A [1]
MR013326 E-3A 17-beta-Estradiol glucuronide Unclear E-3A [2], [3]
MR013324 E-3A 17-beta-Estradiol-3-glucuronide Unclear E-3A [1]
MR013327 E-3A 17alpha-Estradiol-3-glucuronide Unclear E-3A [1]
MR013308 E-3A 17beta-Estradiol-3,17-beta-sulfate Unclear E-3A [4]
MR013313 E-3A 2-hydroxyestrone Oxidation - 2-hydroxylation E-3A [5]
MR013325 E-3A 2-methoxy-17beta-estradiol 3-O-(beta-D-glucuronide) Unclear E-3A [2]
MR013323 E-3A 2-Methoxyestrone 3-glucuronide Unclear E-3A [5]
MR013318 E-3A 4-Hydroxyestradiol Unclear E-3A [6]
MR013315 E-3A 4-hydroxyestrone Oxidation - 4-hydroxylation E-3A [6]
MR013328 E-3A Estradiol-17alpha 3-D-glucuronoside Unclear E-3A [1]
MR013322 E-3A Estradiol-17beta 3-sulfate Unclear E-3A [7]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004101 Conjugated estrogens Estrone Reduction - Reduction Conjugated estrogens [8]
MR004241 Estrone sulfate Estrone Unclear Estrone sulfate [9]
MR000967 Estropipate Estrone Unclear Estropipate [10]
MR013309 17Beta-Estradiol-3,17-beta-sulfate Estrone Unclear E-3A [4]
MR003147 4-androstene-3,17-dione(AD) Estrone Unclear Dehydroepiandrosterone [11]
MR002636 Estradiol Estrone Unclear Estradiol acetate [6]
MR002659 Estradiol Estrone Unclear Estradiol cypionate [6]
MR002682 Estradiol Estrone Unclear Estradiol valerate [6]
MR000957 Estromustine Estrone Unclear Estramustine [12]
MR002637 17beta-Estradiol-3,17-beta-sulfate Estrone Unclear Estradiol acetate [4]
MR002660 17beta-Estradiol-3,17-beta-sulfate Estrone Unclear Estradiol cypionate [4]
MR002683 17beta-Estradiol-3,17-beta-sulfate Estrone Unclear Estradiol valerate [4]
⏷ Show the Full List of MR
References
1 DrugBank(Pharmacology-Metabolism):E-3A
2 The metabolism of estradiol; oral compared to intravenous administration J Steroid Biochem. 1985 Dec;23(6A):1065-70. doi: 10.1016/0022-4731(85)90068-8.
3 Profiling endogenous serum estrogen and estrogen-glucuronides by liquid chromatography-tandem mass spectrometry Anal Chem. 2009 Dec 15;81(24):10143-8. doi: 10.1021/ac9019126.
4 Cytochrome P450 1A2 (CYP1A2) activity and risk factors for breast cancer: a cross-sectional study. Breast Cancer Res. 2004;6(4):R352-65.
5 DrugBank(Pharmacology-Metabolism)Estradiol acetate
6 Cytochrome P450-mediated metabolism of estrogens and its regulation in human. Cancer Lett. 2005 Sep 28;227(2):115-24.
7 FOODB:E-3A
8 Conjugated estrogens and bazedoxifene
9 Estrone Sulfate Transport and Steroid Sulfatase Activity in Colorectal Cancer: Implications for Hormone Replacement Therapy
10 DrugBank(Pharmacology-Metabolism)Estropipate
11 Resveratrol Inhibits Key Steps of Steroid Metabolism in a Human Estrogen-Receptor Positive Breast Cancer Model: Impact on Cellular Proliferation Front Pharmacol. 2018 Jul 10;9:742. doi: 10.3389/fphar.2018.00742.
12 Simultaneous determination of estramustine phosphate and its four metabolites in human plasma by liquid chromatography-ionspray mass spectrometry Biomed Chromatogr. 2004 Jun;18(5):293-301. doi: 10.1002/bmc.319.

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