Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001220)
Formula
SVG example
Oxidation
Reactant Irbesartan Product Irbesartan derivative M3
Reactant Info Product Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001215 Irbesartan Irbesartan derivative M4 Oxidation - Hydroxylation Irbesartan [1], [2]
MR001216 Irbesartan Irbesartan derivative M5 Oxidation - Hydroxylation Irbesartan [1], [2]
MR001217 Irbesartan Irbesartan derivative M7 Oxidation - Hydroxylation Irbesartan [1], [2]
MR001221 Irbesartan Irbesartan derivative M8 Conjugation - N-Glucuronidation Irbesartan [1], [2]
MR001222 Irbesartan Irbesartan metabolite F Oxidation - N-Dealkylation Irbesartan [3]
MR001218 Irbesartan Irbesartan-TP335 Oxidation - Hydrolysis; N-Demethylation Irbesartan [1], [2]
MR001219 Irbesartan SR 49498 Hydrolysis - Hydrolysis Irbesartan [1], [2]
References
1 Biotransformation of irbesartan in man Drug Metab Dispos. 1998 May;26(5):408-17.
2 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
3 Disposition of irbesartan, an angiotensin II AT1-receptor antagonist, in mice, rats, rabbits, and macaques Drug Metab Dispos. 2000 Jan;28(1):79-88.

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