Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001221)
Formula Reactant Irbesartan Product Irbesartan derivative M8
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A3 (UGT1A3) DME Info
Metabolic Type Conjugation - N-Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001220 Irbesartan Irbesartan derivative M3 Oxidation - Oxidation Irbesartan [1], [2]
MR001215 Irbesartan Irbesartan derivative M4 Oxidation - Hydroxylation Irbesartan [1], [2]
MR001216 Irbesartan Irbesartan derivative M5 Oxidation - Hydroxylation Irbesartan [1], [2]
MR001217 Irbesartan Irbesartan derivative M7 Oxidation - Hydroxylation Irbesartan [1], [2]
MR001222 Irbesartan Irbesartan metabolite F Oxidation - N-Dealkylation Irbesartan [3]
MR001218 Irbesartan Irbesartan-TP335 Oxidation - Hydrolysis; N-Demethylation Irbesartan [1], [2]
MR001219 Irbesartan SR 49498 Hydrolysis - Hydrolysis Irbesartan [1], [2]
References
1 Biotransformation of irbesartan in man Drug Metab Dispos. 1998 May;26(5):408-17.
2 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
3 Disposition of irbesartan, an angiotensin II AT1-receptor antagonist, in mice, rats, rabbits, and macaques Drug Metab Dispos. 2000 Jan;28(1):79-88.

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