Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001243)
Formula
SVG example
Denitration
Reactant Isosorbide 5-mononitrate Product Isosorbide
Reactant Info Product Info
Metabolic Type Other reaction - Denitration
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001245 Isosorbide dinitrate Isosorbide 5-mononitrate Other reaction - Denitration Isosorbide dinitrate [1], [2]
MR001250 Isosorbide mononitrate Isosorbide mononitrate Nitric Oxide Unclear Isosorbide mononitrate [3], [4]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001242 Isosorbide 5-mononitrate Isosorbide-5-mononitrate-2-glucuronide Conjugation - Glucuronidation Isosorbide dinitrate [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001249 Isosorbide mononitrate Isosorbide Other reaction - Denitrosylation Isosorbide mononitrate [3]
MR001244 Isosorbide 2-nitrate Isosorbide Other reaction - Denitration Isosorbide dinitrate [1], [2]
References
1 Isosorbide dinitrate bioavailability, kinetics, and metabolism Clin Pharmacol Ther. 1985 Aug;38(2):140-9. doi: 10.1038/clpt.1985.150.
2 Pharmacokinetics and metabolism of isosorbide-dinitrate after intravenous and oral administration Eur J Clin Pharmacol. 1985;27(6):637-44. doi: 10.1007/BF00547041.
3 Pharmacokinetics of isosorbide mononitrate Am J Cardiol. 1992 Nov 27;70(17):61G-66G. doi: 10.1016/0002-9149(92)90028-w.
4 Isoforms of cytochrome P450 on organic nitrate-derived nitric oxide release in human heart vessels. FEBS Lett. 1999 Jun 11;452(3):165-9.

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