Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001249)
Formula
SVG example
Denitrosylation
Reactant Isosorbide mononitrate Product Isosorbide
Reactant Info Product Info
Metabolic Type Other reaction - Denitrosylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001250 Isosorbide mononitrate Isosorbide mononitrate Nitric Oxide Unclear Isosorbide mononitrate [1], [2]
MR001248 Isosorbide mononitrate Isosorbide-5-mononitrate-2-glucuronide Conjugation - O-Glucuronidation Isosorbide mononitrate [1]
MR001251 Isosorbide mononitrate Sorbitol Other reaction - Denitrosylation Isosorbide mononitrate [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001244 Isosorbide 2-nitrate Isosorbide Other reaction - Denitration Isosorbide dinitrate [3], [4]
MR001243 Isosorbide 5-mononitrate Isosorbide Other reaction - Denitration Isosorbide dinitrate [3], [4]
References
1 Pharmacokinetics of isosorbide mononitrate Am J Cardiol. 1992 Nov 27;70(17):61G-66G. doi: 10.1016/0002-9149(92)90028-w.
2 Isoforms of cytochrome P450 on organic nitrate-derived nitric oxide release in human heart vessels. FEBS Lett. 1999 Jun 11;452(3):165-9.
3 Isosorbide dinitrate bioavailability, kinetics, and metabolism Clin Pharmacol Ther. 1985 Aug;38(2):140-9. doi: 10.1038/clpt.1985.150.
4 Pharmacokinetics and metabolism of isosorbide-dinitrate after intravenous and oral administration Eur J Clin Pharmacol. 1985;27(6):637-44. doi: 10.1007/BF00547041.

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