Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001328)
Formula Reactant Diazepam Product Nordazepam
Reactant Info Product Info
Metabolic Enzyme Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000820 Diazepam Oxazepam Oxidation - N-Demethylation Diazepam [1], [2], [3]
MR000821 Diazepam Temazepam Oxidation - 3-Hydroxylation Diazepam [1], [2], [3]
MR005845 Diazepam Medazepam metabolite Unclear Medazepam [4], [5]
MR001329 Diazepam Temazepam Unclear Ketazolam [6]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011243 Chlordiazepoxide Desmethyldiazepam Unclear - Unclear Chlordiazepoxide [7]
MR005298 Clorazepic acid Nordazepam Oxidation - N-demethylation Clorazepic acid [8]
MR011025 Halazepam Desmethyl-diazepam Unclear - Unclear Halazepam [9]
MR002107 Prazepam Nordazepam Oxidation - N-Dealkylation Prazepam [10], [11], [12]
MR005840 Medazepam metabolite Medazepam metabolite Unclear Medazepam [4], [13]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011026 Desmethyl-diazepam Oxazepam Unclear - Unclear Halazepam [9]
MR005841 Medazepam metabolite Oxazepam Unclear Medazepam [4], [13]
References
1 DrugBank(Pharmacology-Metabolism)Diazepam
2 Pharmacokinetics of Diazepam and Its Metabolites in Urine of Chinese Participants. Drugs R D. 2022 Mar;22(1):43-50. doi: 10.1007/s40268-021-00375-y.
3 Kinetic disposition of diazepam and its metabolites after intravenous administration of diazepam in the horse: Relevance for doping control. J Vet Pharmacol Ther. 2021 Sep;44(5):733-744. doi: 10.1111/jvp.12991.
4 Metabolism of 14C-medazepam hydrochloride in dog, rat and man
5 Plasma concentrations of medazepam and its metabolites after oral administration
6 Urinary diazepam metabolite distribution in a chronic pain population J Anal Toxicol. 2014 Apr;38(3):135-42. doi: 10.1093/jat/bku001.
7 Postmortem Brain and Blood Reference Concentrations of Alprazolam, Bromazepam, Chlordiazepoxide, Diazepam, and their Metabolites and a Review of the Literature
8 Determination of clorazepate and its major metabolites in blood and urine by electron capture gas-liquid chromatography
9 Pharmacokinetics and metabolism of halazepam in naive and dependent dogs
10 Metabolic profile of oxazepam and related benzodiazepines: clinical and forensic aspects. Drug Metab Rev. 2017 Nov;49(4):451-463.
11 Prazepam metabolism by man Clin Pharmacol Ther. 1970 Nov-Dec;11(6):890-7. doi: 10.1002/cpt1970116890.
12 Prazepam metabolites in dog urine J Pharm Sci. 1970 Mar;59(3):322-5. doi: 10.1002/jps.2600590309.
13 Further studies on medazepam metabolism in the rat

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