Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001346)
Formula Reactant Ketoconazole dihydroxyl intermediate Product M3 (Ketoconazole)
Reactant Info Product Info
Metabolic Type Oxidation - N-Dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001344 Ketoconazole epoxide intermediate Ketoconazole dihydroxyl intermediate Other reaction - Hydration Ketoconazole [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001347 Ketoconazole dihydroxyl intermediate M5' (Ketoconazole) Oxidation - Oxidation Ketoconazole [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001348 M3 (Ketoconazole) M4 (Ketoconazole) Oxidation - N-Dealkylation Ketoconazole [1]
References
1 Revisiting the metabolism of ketoconazole using accurate mass Drug Metab Lett. 2009 Aug;3(3):191-8. doi: 10.2174/187231209789352085.

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