Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001421)
Formula Reactant N-dealkylated lapatinib Product Nitroso intermediate
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001428 Lapatinib ditosylate N-dealkylated lapatinib Oxidation - N-Dealkylation Lapatinib ditosylate [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001423 N-hydroxy lapatinib Nitroso intermediate Unclear Lapatinib ditosylate [1]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001422 Nitroso intermediate Lapatinib ditosylate metabolite M2 Unclear Lapatinib ditosylate [1]
References
1 Metabolic intermediate complex formation of human cytochrome P450 3A4 by lapatinib Drug Metab Dispos. 2011 Jun;39(6):1022-30. doi: 10.1124/dmd.110.037531.

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